article · 01/01/2013
A nanoliter-scale open chemical reactor
Résumé
An open chemical reactor is a container that exchanges matter with the exterior. Well-mixed open chemical reactors, called continuous stirred tank reactors (CSTR), have been instrumental for investigating the dynamics of out-of-equilibrium chemical processes, such as oscillations, bistability, and chaos. Here, we introduce a microfluidic CSTR, called mu CSTR, that reduces reagent consumption by six orders of magnitude. It consists of an annular reactor with four inlets and one outlet fabricated in PDMS using multi-layer soft lithography. A monolithic peristaltic pump feeds fresh reagents into the reactor through the inlets. After each injection the content of the reactor is continuously mixed with a second peristaltic pump. The efficiency of the mCSTR is experimentally characterized using a bromate, sulfite, ferrocyanide pH oscillator. Simulations accounting for the digital injection process are in agreement with experimental results. The low consumption of the mCSTR will be advantageous for investigating out-of-equilibrium dynamics of chemical processes involving biomolecules. These studies have been scarce so far because a miniaturized version of a CSTR was not available.
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Galas, J.-C., Haghiri-Gosnet, A.-M., & Estevez-Torres, A. (2013). A nanoliter-scale open chemical reactor. Lab Chip, 13(3). https://doi.org/10.1039/c2lc40649g@article{Galas2013_92,
author = {Galas, Jean-Christophe and Haghiri-Gosnet, Anne-Marie and Estevez-Torres, Andre},
year = {2013},
month = {1},
title = {A nanoliter-scale open chemical reactor},
journal = {Lab Chip},
publisher = {ROYAL SOC CHEMISTRY},
volume = {13},
number = {3},
address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
abstract = {An open chemical reactor is a container that exchanges matter with the exterior. Well-mixed open chemical reactors, called continuous stirred tank reactors (CSTR), have been instrumental for investigating the dynamics of out-of-equilibrium chemical processes, such as oscillations, bistability, and chaos. Here, we introduce a microfluidic CSTR, called mu CSTR, that reduces reagent consumption by six orders of magnitude. It consists of an annular reactor with four inlets and one outlet fabricated in PDMS using multi-layer soft lithography. A monolithic peristaltic pump feeds fresh reagents into the reactor through the inlets. After each injection the content of the reactor is continuously mixed with a second peristaltic pump. The efficiency of the mCSTR is experimentally characterized using a bromate, sulfite, ferrocyanide pH oscillator. Simulations accounting for the digital injection process are in agreement with experimental results. The low consumption of the mCSTR will be advantageous for investigating out-of-equilibrium dynamics of chemical processes involving biomolecules. These studies have been scarce so far because a miniaturized version of a CSTR was not available.},
url = {http://www.dx.doi.org/10.1039/c2lc40649g},
doi = {10.1039/c2lc40649g},
issn = {1473-0197},
}TY - JOUR
AU - Galas, Jean-Christophe
AU - Haghiri-Gosnet, Anne-Marie
AU - Estevez-Torres, Andre
PY - 2013
DA - 2013/01/01
TI - A nanoliter-scale open chemical reactor
JO - Lab Chip
VL - 13
IS - 3
PB - ROYAL SOC CHEMISTRY
SN - 1473-0197
AB - An open chemical reactor is a container that exchanges matter with the exterior. Well-mixed open chemical reactors, called continuous stirred tank reactors (CSTR), have been instrumental for investigating the dynamics of out-of-equilibrium chemical processes, such as oscillations, bistability, and chaos. Here, we introduce a microfluidic CSTR, called mu CSTR, that reduces reagent consumption by six orders of magnitude. It consists of an annular reactor with four inlets and one outlet fabricated in PDMS using multi-layer soft lithography. A monolithic peristaltic pump feeds fresh reagents into the reactor through the inlets. After each injection the content of the reactor is continuously mixed with a second peristaltic pump. The efficiency of the mCSTR is experimentally characterized using a bromate, sulfite, ferrocyanide pH oscillator. Simulations accounting for the digital injection process are in agreement with experimental results. The low consumption of the mCSTR will be advantageous for investigating out-of-equilibrium dynamics of chemical processes involving biomolecules. These studies have been scarce so far because a miniaturized version of a CSTR was not available.
DO - 10.1039/c2lc40649g
UR - http://www.dx.doi.org/10.1039/c2lc40649g
ER -