proceeding · 01/01/2012
Spectral and lifetime domain measurements of rat brain tumours
Résumé
During glioblastoma surgery, delineation of the brain tumour margins remains difficult especially since infiltrated and normal tissues have the same visual appearance. This problematic constitutes our research interest. We developed a fibre-optical fluorescence probe for spectroscopic and time domain measurements. First measurements of endogenous tissue fluorescence were performed on fresh and fixed rat tumour brain slices. Spectral characteristics, fluorescence redox ratios and fluorescence lifetime measurements were analysed. Fluorescence information collected from both, lifetime and spectroscopic experiments, appeared promising for tumour tissue discrimination. Two photon measurements were performed on the same fixed tissue. Different wavelengths are used to acquire two-photon excitation-fluorescence of tumorous and healthy sites.
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Abi, H.-D., Leh, B., Allaoua, K., Genoux, A., Siebert, R., Steffenhagen, M., Peyrot, D., Sandeau, N., Vever-Bizet, C., Bourg-Heckly, G., Chebbi, I., & Collado-Hilly, M. (2012). Spectral and lifetime domain measurements of rat brain tumours. PHOTONIC THERAPEUTICS AND DIAGNOSTICS VIII, PTS 1 AND 2, 8207(82074P). https://doi.org/10.1117/12.907411@inproceedings{Abi2012_83,
author = {Abi, Haidar D. and Leh, B. and Allaoua, K. and Genoux, A. and Siebert, R. and Steffenhagen, M. and Peyrot, D. and Sandeau, N. and Vever-Bizet, C. and Bourg-Heckly, G. and Chebbi, I. and Collado-Hilly, M.},
year = {2012},
month = {1},
title = {Spectral and lifetime domain measurements of rat brain tumours},
booktitle = {PHOTONIC THERAPEUTICS AND DIAGNOSTICS VIII, PTS 1 AND 2},
volume = {8207},
number = {82074P},
series = {Proceedings of SPIE},
abstract = {During glioblastoma surgery, delineation of the brain tumour margins remains difficult especially since infiltrated and normal tissues have the same visual appearance. This problematic constitutes our research interest. We developed a fibre-optical fluorescence probe for spectroscopic and time domain measurements. First measurements of endogenous tissue fluorescence were performed on fresh and fixed rat tumour brain slices. Spectral characteristics, fluorescence redox ratios and fluorescence lifetime measurements were analysed. Fluorescence information collected from both, lifetime and spectroscopic experiments, appeared promising for tumour tissue discrimination. Two photon measurements were performed on the same fixed tissue. Different wavelengths are used to acquire two-photon excitation-fluorescence of tumorous and healthy sites.},
note = {Conference on Photonic Therapeutics and Diagnostics VIII, San Francisco, CA, JAN 21-24, 2012},
url = {http://www.dx.doi.org/10.1117/12.907411},
doi = {10.1117/12.907411},
issn = {0277-786X},
}TY - CONF
AU - Abi, Haidar D.
AU - Leh, B.
AU - Allaoua, K.
AU - Genoux, A.
AU - Siebert, R.
AU - Steffenhagen, M.
AU - Peyrot, D.
AU - Sandeau, N.
AU - Vever-Bizet, C.
AU - Bourg-Heckly, G.
AU - Chebbi, I.
AU - Collado-Hilly, M.
PY - 2012
DA - 2012/01/01
TI - Spectral and lifetime domain measurements of rat brain tumours
BT - PHOTONIC THERAPEUTICS AND DIAGNOSTICS VIII, PTS 1 AND 2
VL - 8207
IS - 82074P
SN - 0277-786X
AB - During glioblastoma surgery, delineation of the brain tumour margins remains difficult especially since infiltrated and normal tissues have the same visual appearance. This problematic constitutes our research interest. We developed a fibre-optical fluorescence probe for spectroscopic and time domain measurements. First measurements of endogenous tissue fluorescence were performed on fresh and fixed rat tumour brain slices. Spectral characteristics, fluorescence redox ratios and fluorescence lifetime measurements were analysed. Fluorescence information collected from both, lifetime and spectroscopic experiments, appeared promising for tumour tissue discrimination. Two photon measurements were performed on the same fixed tissue. Different wavelengths are used to acquire two-photon excitation-fluorescence of tumorous and healthy sites.
DO - 10.1117/12.907411
UR - http://www.dx.doi.org/10.1117/12.907411
ER -