article · 01/06/2013
Magnetic and Photoresponsive Theranosomes: Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy
Résumé
Cell-released vesicles are natural carriers that circulate in body fluids and transport biological agents to distal cells. As nature uses vesicles in cell communication to promote tumor progression, we propose to harness their unique properties and exploit these biogenic carriers as Trojan horses to deliver therapeutic payloads to cancer cells. In a theranostic approach, cell-released vesicles were engineered by a top-down procedure from precursor cells, previously loaded with a photosensitizer and magnetic nanoparticles. The double exogenous cargo provided vesicles with magnetic and optical responsiveness allowing therapeutic and imaging functions. This new class of cell-derived smart nanovectors was named ``theranosomes{''}. Theranosomes enabled efficient photodynamic tumor therapy in a murine cancer model in vivo. Moreover the distribution of this biogenic vector could be monitored by dual-mode imaging, combining fluorescence and MRI. This study reports the first success in translating a cell communication mediator into a smart theranostic nanovector.
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Silva, A.-K.-A., Kolosnjaj-Tabi, J., Bonneau, S., Marangon, I., Boggetto, N., Aubertin, K., Clement, O., Bureau, M.-F., Luciani, N., Gazeau, F., & Wilhelm, C. (2013). Magnetic and Photoresponsive Theranosomes: Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy. ACS Nano, 7(6), 4954-4966. https://doi.org/10.1021/nn400269x@article{Silva2013_57,
author = {Silva, Amanda K. A. and Kolosnjaj-Tabi, Jelena and Bonneau, Stephanie and Marangon, Iris and Boggetto, Nicole and Aubertin, Kelly and Clement, Olivier and Bureau, Michel Francis and Luciani, Nathalie and Gazeau, Florence and Wilhelm, Claire},
year = {2013},
month = {6},
title = {Magnetic and Photoresponsive Theranosomes: Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy},
journal = {ACS Nano},
volume = {7},
number = {6},
pages = {4954-4966},
abstract = {Cell-released vesicles are natural carriers that circulate in body fluids and transport biological agents to distal cells. As nature uses vesicles in cell communication to promote tumor progression, we propose to harness their unique properties and exploit these biogenic carriers as Trojan horses to deliver therapeutic payloads to cancer cells. In a theranostic approach, cell-released vesicles were engineered by a top-down procedure from precursor cells, previously loaded with a photosensitizer and magnetic nanoparticles. The double exogenous cargo provided vesicles with magnetic and optical responsiveness allowing therapeutic and imaging functions. This new class of cell-derived smart nanovectors was named ``theranosomes\{''\}. Theranosomes enabled efficient photodynamic tumor therapy in a murine cancer model in vivo. Moreover the distribution of this biogenic vector could be monitored by dual-mode imaging, combining fluorescence and MRI. This study reports the first success in translating a cell communication mediator into a smart theranostic nanovector.},
url = {http://www.dx.doi.org/10.1021/nn400269x},
doi = {10.1021/nn400269x},
issn = {1936-0851},
}TY - JOUR
AU - Silva, Amanda K. A.
AU - Kolosnjaj-Tabi, Jelena
AU - Bonneau, Stephanie
AU - Marangon, Iris
AU - Boggetto, Nicole
AU - Aubertin, Kelly
AU - Clement, Olivier
AU - Bureau, Michel Francis
AU - Luciani, Nathalie
AU - Gazeau, Florence
AU - Wilhelm, Claire
PY - 2013
DA - 2013/06/01
TI - Magnetic and Photoresponsive Theranosomes: Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy
JO - ACS Nano
VL - 7
IS - 6
SN - 1936-0851
AB - Cell-released vesicles are natural carriers that circulate in body fluids and transport biological agents to distal cells. As nature uses vesicles in cell communication to promote tumor progression, we propose to harness their unique properties and exploit these biogenic carriers as Trojan horses to deliver therapeutic payloads to cancer cells. In a theranostic approach, cell-released vesicles were engineered by a top-down procedure from precursor cells, previously loaded with a photosensitizer and magnetic nanoparticles. The double exogenous cargo provided vesicles with magnetic and optical responsiveness allowing therapeutic and imaging functions. This new class of cell-derived smart nanovectors was named ``theranosomes{''}. Theranosomes enabled efficient photodynamic tumor therapy in a murine cancer model in vivo. Moreover the distribution of this biogenic vector could be monitored by dual-mode imaging, combining fluorescence and MRI. This study reports the first success in translating a cell communication mediator into a smart theranostic nanovector.
SP - 4954
EP - 4966
DO - 10.1021/nn400269x
UR - http://www.dx.doi.org/10.1021/nn400269x
ER -