article · 10/05/2013
Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?
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Résumé
Mitochondrial dynamics is a recent topic of research in the field of cardiac physiology. The study of mechanisms involved in the morphological changes and in the mobility of mitochondria is legitimate since the adult cardiomyocytes possess numerous mitochondria which occupy at least 30\% of cell volume. However, architectural constraints exist in the cardiomyocyte that limit mitochondrial movements and communication between adjacent mitochondria. Still, the proteins involved in mitochondria' fusion and fission are highly expressed in these cells and could be involved in different processes important for the cardiac function. For example, they are required for mitochondrial biogenesis to synthesize new mitochondria and for the quality-control of the organelles. They are also involved in inner membrane organization and may play a role in apoptosis. More generally, change in mitochondrial morphology can have consequences in the functioning of the respiratory chain, in the regulation of the mitochondrial permeability transition pore (MPTP), and in the interactions with other organelles. Furthermore, the proteins involved in fusion and fission of mitochondria are altered in cardiac pathologies such as ischemia/reperfusion or heart failure (HF), and appear to be valuable targets for pharmacological therapies. Thus, mitochondria' dynamics deserves particular attention in cardiac research. The present review draws up a report of our knowledge on these phenomena
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Piquereau, J., Caffin, F., Novotova, M., Lemaire, C., Veksler, V., Garnier, A., Ventura-Clapier, R., & Joubert, F. (2013). Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?. Front. Physiol., 4(102), 1-12. https://doi.org/10.3389/fphys.2013.00102@article{Piquereau2013_52,
author = {Piquereau, Jerome and Caffin, Fanny and Novotova, Marta and Lemaire, Christophe and Veksler, Vladimir and Garnier, Anne and Ventura-Clapier, Renee and Joubert, Frederic},
year = {2013},
month = {5},
title = {Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?},
journal = {Front. Physiol.},
publisher = {FRONTIERS RESEARCH FOUNDATION},
volume = {4},
number = {102},
pages = {1-12},
address = {PO BOX 110, LAUSANNE, 1015, SWITZERLAND},
abstract = {Mitochondrial dynamics is a recent topic of research in the field of cardiac physiology. The study of mechanisms involved in the morphological changes and in the mobility of mitochondria is legitimate since the adult cardiomyocytes possess numerous mitochondria which occupy at least 30\textbackslash{}\% of cell volume. However, architectural constraints exist in the cardiomyocyte that limit mitochondrial movements and communication between adjacent mitochondria. Still, the proteins involved in mitochondria' fusion and fission are highly expressed in these cells and could be involved in different processes important for the cardiac function. For example, they are required for mitochondrial biogenesis to synthesize new mitochondria and for the quality-control of the organelles. They are also involved in inner membrane organization and may play a role in apoptosis. More generally, change in mitochondrial morphology can have consequences in the functioning of the respiratory chain, in the regulation of the mitochondrial permeability transition pore (MPTP), and in the interactions with other organelles. Furthermore, the proteins involved in fusion and fission of mitochondria are altered in cardiac pathologies such as ischemia/reperfusion or heart failure (HF), and appear to be valuable targets for pharmacological therapies. Thus, mitochondria' dynamics deserves particular attention in cardiac research. The present review draws up a report of our knowledge on these phenomena},
url = {http://www.dx.doi.org/10.3389/fphys.2013.00102},
doi = {10.3389/fphys.2013.00102},
issn = {1664-042X},
}TY - JOUR
AU - Piquereau, Jerome
AU - Caffin, Fanny
AU - Novotova, Marta
AU - Lemaire, Christophe
AU - Veksler, Vladimir
AU - Garnier, Anne
AU - Ventura-Clapier, Renee
AU - Joubert, Frederic
PY - 2013
DA - 2013/05/10
TI - Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?
JO - Front. Physiol.
VL - 4
IS - 102
PB - FRONTIERS RESEARCH FOUNDATION
SN - 1664-042X
AB - Mitochondrial dynamics is a recent topic of research in the field of cardiac physiology. The study of mechanisms involved in the morphological changes and in the mobility of mitochondria is legitimate since the adult cardiomyocytes possess numerous mitochondria which occupy at least 30\% of cell volume. However, architectural constraints exist in the cardiomyocyte that limit mitochondrial movements and communication between adjacent mitochondria. Still, the proteins involved in mitochondria' fusion and fission are highly expressed in these cells and could be involved in different processes important for the cardiac function. For example, they are required for mitochondrial biogenesis to synthesize new mitochondria and for the quality-control of the organelles. They are also involved in inner membrane organization and may play a role in apoptosis. More generally, change in mitochondrial morphology can have consequences in the functioning of the respiratory chain, in the regulation of the mitochondrial permeability transition pore (MPTP), and in the interactions with other organelles. Furthermore, the proteins involved in fusion and fission of mitochondria are altered in cardiac pathologies such as ischemia/reperfusion or heart failure (HF), and appear to be valuable targets for pharmacological therapies. Thus, mitochondria' dynamics deserves particular attention in cardiac research. The present review draws up a report of our knowledge on these phenomena
SP - 1
EP - 12
DO - 10.3389/fphys.2013.00102
UR - http://www.dx.doi.org/10.3389/fphys.2013.00102
ER -