article · 30/11/2015
Release kinetics of an amphiphilic photosensitizer by block-polymer nanoparticles
Résumé
Block-polymer nanoparticles are now well-known candidates for the delivery of various non-soluble drugs to cells. The release of drugs from these nanoparticles is a major concern related to their efficiency as nanovectors and is still not completely deciphered. Various processes have been identified, depending of both the nature of the block-polymer and those of the drugs used. We focused our interest on an amphiphilic photosensitizer studied for photodynamic treatments of cancer, Pheophorbide-a (Pheo). We studied the transfer of Pheo from poly(ethyleneglycol-b-epsilon-caprolactone) nanoparticles (I) to MCF-7 cancer cells and (II) to models of membranes. Altogether, our results suggest that the delivery of the major part of the Pheo by the nanoparticles occurs via a direct transfer of Pheo from the nanoparticles to the membrane, by collision. A minor process may involve the internalization of a small amount of the nanoplatforms by the cells. So, this research illustrates the great care necessary to address the question of the choice of such nanocarriers, in relation with the properties - in particular the relative hydrophobicity - of the drugs encapsulated, and gives elements to predict the mechanism and the efficiency of the delivery. (C) 2015 Elsevier B.V. All rights reserved.
Citer cet article
Kerdous, R., Sureau, F., Bour, A., & Bonneau, S. (2015). Release kinetics of an amphiphilic photosensitizer by block-polymer nanoparticles. Int. J. Pharm., 495(2), 750-760. https://doi.org/10.1016/j.ijpharm.2015.09.032@article{Kerdous2015_44,
author = {Kerdous, Rachid and Sureau, Franck and Bour, Aurelien and Bonneau, Stephanie},
year = {2015},
month = {11},
title = {Release kinetics of an amphiphilic photosensitizer by block-polymer nanoparticles},
journal = {Int. J. Pharm.},
publisher = {ELSEVIER SCIENCE BV},
volume = {495},
number = {2},
pages = {750-760},
address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS},
abstract = {Block-polymer nanoparticles are now well-known candidates for the delivery of various non-soluble drugs to cells. The release of drugs from these nanoparticles is a major concern related to their efficiency as nanovectors and is still not completely deciphered. Various processes have been identified, depending of both the nature of the block-polymer and those of the drugs used. We focused our interest on an amphiphilic photosensitizer studied for photodynamic treatments of cancer, Pheophorbide-a (Pheo). We studied the transfer of Pheo from poly(ethyleneglycol-b-epsilon-caprolactone) nanoparticles (I) to MCF-7 cancer cells and (II) to models of membranes. Altogether, our results suggest that the delivery of the major part of the Pheo by the nanoparticles occurs via a direct transfer of Pheo from the nanoparticles to the membrane, by collision. A minor process may involve the internalization of a small amount of the nanoplatforms by the cells. So, this research illustrates the great care necessary to address the question of the choice of such nanocarriers, in relation with the properties - in particular the relative hydrophobicity - of the drugs encapsulated, and gives elements to predict the mechanism and the efficiency of the delivery. (C) 2015 Elsevier B.V. All rights reserved.},
url = {http://www.dx.doi.org/10.1016/j.ijpharm.2015.09.032},
doi = {10.1016/j.ijpharm.2015.09.032},
issn = {0378-5173},
}TY - JOUR
AU - Kerdous, Rachid
AU - Sureau, Franck
AU - Bour, Aurelien
AU - Bonneau, Stephanie
PY - 2015
DA - 2015/11/30
TI - Release kinetics of an amphiphilic photosensitizer by block-polymer nanoparticles
JO - Int. J. Pharm.
VL - 495
IS - 2
PB - ELSEVIER SCIENCE BV
SN - 0378-5173
AB - Block-polymer nanoparticles are now well-known candidates for the delivery of various non-soluble drugs to cells. The release of drugs from these nanoparticles is a major concern related to their efficiency as nanovectors and is still not completely deciphered. Various processes have been identified, depending of both the nature of the block-polymer and those of the drugs used. We focused our interest on an amphiphilic photosensitizer studied for photodynamic treatments of cancer, Pheophorbide-a (Pheo). We studied the transfer of Pheo from poly(ethyleneglycol-b-epsilon-caprolactone) nanoparticles (I) to MCF-7 cancer cells and (II) to models of membranes. Altogether, our results suggest that the delivery of the major part of the Pheo by the nanoparticles occurs via a direct transfer of Pheo from the nanoparticles to the membrane, by collision. A minor process may involve the internalization of a small amount of the nanoplatforms by the cells. So, this research illustrates the great care necessary to address the question of the choice of such nanocarriers, in relation with the properties - in particular the relative hydrophobicity - of the drugs encapsulated, and gives elements to predict the mechanism and the efficiency of the delivery. (C) 2015 Elsevier B.V. All rights reserved.
SP - 750
EP - 760
DO - 10.1016/j.ijpharm.2015.09.032
UR - http://www.dx.doi.org/10.1016/j.ijpharm.2015.09.032
ER -