article · 04/01/2022
Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity
Résumé
The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that includes hydrodynamic flow and resulting gradients of food and bacterial concentrations. We find that this fixation probability is substantially increased, compared with an equivalent well-mixed system, in the regime where the profiles of food and bacterial concentration are strongly spatially dependent. Fixation probability then becomes independent of total population size. We show that our results can be rationalized by introducing an active population, which consists of those bacteria that are actively consuming food and dividing. The active population size yields an effective population size for neutral mutant fixation probability in the gut.
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Labavic, D., Loverdo, C., & Bitbol, A.-F. (2022). Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity. Proc. Natl. Acad. Sci. U. S. A., 119(1). https://doi.org/10.1073/pnas.2108671119@article{Labavic2022_349,
author = {Labavic, Darka and Loverdo, Claude and Bitbol, Anne-Florence},
year = {2022},
month = {1},
title = {Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity},
journal = {Proc. Natl. Acad. Sci. U. S. A.},
publisher = {NATL ACAD SCIENCES},
volume = {119},
number = {1},
address = {2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA},
abstract = {The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that includes hydrodynamic flow and resulting gradients of food and bacterial concentrations. We find that this fixation probability is substantially increased, compared with an equivalent well-mixed system, in the regime where the profiles of food and bacterial concentration are strongly spatially dependent. Fixation probability then becomes independent of total population size. We show that our results can be rationalized by introducing an active population, which consists of those bacteria that are actively consuming food and dividing. The active population size yields an effective population size for neutral mutant fixation probability in the gut.},
url = {http://www.dx.doi.org/10.1073/pnas.2108671119},
doi = {10.1073/pnas.2108671119},
issn = {0027-8424},
}TY - JOUR
AU - Labavic, Darka
AU - Loverdo, Claude
AU - Bitbol, Anne-Florence
PY - 2022
DA - 2022/01/04
TI - Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity
JO - Proc. Natl. Acad. Sci. U. S. A.
VL - 119
IS - 1
PB - NATL ACAD SCIENCES
SN - 0027-8424
AB - The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that includes hydrodynamic flow and resulting gradients of food and bacterial concentrations. We find that this fixation probability is substantially increased, compared with an equivalent well-mixed system, in the regime where the profiles of food and bacterial concentration are strongly spatially dependent. Fixation probability then becomes independent of total population size. We show that our results can be rationalized by introducing an active population, which consists of those bacteria that are actively consuming food and dividing. The active population size yields an effective population size for neutral mutant fixation probability in the gut.
DO - 10.1073/pnas.2108671119
UR - http://www.dx.doi.org/10.1073/pnas.2108671119
ER -