article · 05/08/2020
Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field
Résumé
As the places where most of the fuel of the cell, namely, ATP, is synthesized, mitochondria are crucial organelles in eukaryotic cells. The shape of the invaginations of the mitochondria inner membrane, known as a crista, has been identified as a signature of the energetic state of the organelle. However, the interplay between the rate of ATP synthesis and the crista shape remains unclear. In this work, we investigate the crista membrane deformations using a pH-dependent Helfrich model, maintained out of equilibrium by a diffusive flux of protons. This model gives rise to shape changes of a cylindrical invagination, in particular to the formation of necks between wider zones under variable, and especially oscillating, proton flux.
Citer cet article
Patil, N., Bonneau, S., Joubert, F., Bitbol, A.-F., & Berthoumieux, H. (2020). Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field. Phys. Rev. E, 102(2), 022401. https://doi.org/10.1103/PhysRevE.102.022401@article{Patil2020_331,
author = {Patil, Nabil and Bonneau, Stéphanie and Joubert, Frédéric and Bitbol, Anne-Florence and Berthoumieux, Hélène},
year = {2020},
month = {8},
title = {Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field},
journal = {Phys. Rev. E},
volume = {102},
number = {2},
pages = {022401},
abstract = {As the places where most of the fuel of the cell, namely, ATP, is synthesized, mitochondria are crucial organelles in eukaryotic cells. The shape of the invaginations of the mitochondria inner membrane, known as a crista, has been identified as a signature of the energetic state of the organelle. However, the interplay between the rate of ATP synthesis and the crista shape remains unclear. In this work, we investigate the crista membrane deformations using a pH-dependent Helfrich model, maintained out of equilibrium by a diffusive flux of protons. This model gives rise to shape changes of a cylindrical invagination, in particular to the formation of necks between wider zones under variable, and especially oscillating, proton flux.},
doi = {10.1103/PhysRevE.102.022401},
}TY - JOUR
AU - Patil, Nabil
AU - Bonneau, Stéphanie
AU - Joubert, Frédéric
AU - Bitbol, Anne-Florence
AU - Berthoumieux, Hélène
PY - 2020
DA - 2020/08/05
TI - Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field
JO - Phys. Rev. E
VL - 102
IS - 2
AB - As the places where most of the fuel of the cell, namely, ATP, is synthesized, mitochondria are crucial organelles in eukaryotic cells. The shape of the invaginations of the mitochondria inner membrane, known as a crista, has been identified as a signature of the energetic state of the organelle. However, the interplay between the rate of ATP synthesis and the crista shape remains unclear. In this work, we investigate the crista membrane deformations using a pH-dependent Helfrich model, maintained out of equilibrium by a diffusive flux of protons. This model gives rise to shape changes of a cylindrical invagination, in particular to the formation of necks between wider zones under variable, and especially oscillating, proton flux.
SP - 022401
DO - 10.1103/PhysRevE.102.022401
ER -