article · 07/08/2011
Energy maps, side chain conformational flexibility, and vibrational features of polar amino acids L-serine and L-threonine in aqueous environment
Résumé
A comprehensive description of the energetic, conformational, and vibrational features of the two amino acids (AAs) with polar side chains, i.e., serine and threonine, in aqueous environment, is provided. To adequately analyze the side chain conformational flexibility of these amino acids, we resorted to quantum mechanical calculations with the use of density functional theory, which allowed the determination of the energetic features of these AAs through 236 clusters. Each cluster contains a zwitterionic AA surrounded by seven explicit water molecules. The obtained data could evidence the effect of the side chain conformational angle (chi(1) and chi(2)) as well as the location of water molecules on the energy landscapes of both AAs. Four of the lowest energy clusters of each AA, which give rise to distinct side chain conformations, were selected in order to reproduce the FT-IR and Raman spectra recorded in aqueous solutions and to assign the vibrational modes responsible of the main observed bands. (C) 2011 American Institute of Physics. {[}doi:10.1063/1.3617415]
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Hernandez, B., Pflueger, F., Adenier, A., Nsangou, M., Kruglik, S.-G., & Ghomi, M. (2011). Energy maps, side chain conformational flexibility, and vibrational features of polar amino acids L-serine and L-threonine in aqueous environment. Journal of Chemical Physics, 135(5), 055101.1 - 055101.7. https://doi.org/10.1063/1.3617415@article{Hernandez2011_33,
author = {Hernandez, Belen and Pflueger, Fernando and Adenier, Alain and Nsangou, Mama and Kruglik, Sergei G. and Ghomi, Mahmoud},
year = {2011},
month = {8},
title = {Energy maps, side chain conformational flexibility, and vibrational features of polar amino acids L-serine and L-threonine in aqueous environment},
journal = {Journal of Chemical Physics},
publisher = {AMER INST PHYSICS},
volume = {135},
number = {5},
pages = {055101.1 - 055101.7},
address = {1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA},
abstract = {A comprehensive description of the energetic, conformational, and vibrational features of the two amino acids (AAs) with polar side chains, i.e., serine and threonine, in aqueous environment, is provided. To adequately analyze the side chain conformational flexibility of these amino acids, we resorted to quantum mechanical calculations with the use of density functional theory, which allowed the determination of the energetic features of these AAs through 236 clusters. Each cluster contains a zwitterionic AA surrounded by seven explicit water molecules. The obtained data could evidence the effect of the side chain conformational angle (chi(1) and chi(2)) as well as the location of water molecules on the energy landscapes of both AAs. Four of the lowest energy clusters of each AA, which give rise to distinct side chain conformations, were selected in order to reproduce the FT-IR and Raman spectra recorded in aqueous solutions and to assign the vibrational modes responsible of the main observed bands. (C) 2011 American Institute of Physics. \{[\}doi:10.1063/1.3617415]},
url = {http://www.dx.doi.org/10.1063/1.3617415},
doi = {10.1063/1.3617415},
issn = {0021-9606},
}TY - JOUR
AU - Hernandez, Belen
AU - Pflueger, Fernando
AU - Adenier, Alain
AU - Nsangou, Mama
AU - Kruglik, Sergei G.
AU - Ghomi, Mahmoud
PY - 2011
DA - 2011/08/07
TI - Energy maps, side chain conformational flexibility, and vibrational features of polar amino acids L-serine and L-threonine in aqueous environment
JO - Journal of Chemical Physics
VL - 135
IS - 5
PB - AMER INST PHYSICS
SN - 0021-9606
AB - A comprehensive description of the energetic, conformational, and vibrational features of the two amino acids (AAs) with polar side chains, i.e., serine and threonine, in aqueous environment, is provided. To adequately analyze the side chain conformational flexibility of these amino acids, we resorted to quantum mechanical calculations with the use of density functional theory, which allowed the determination of the energetic features of these AAs through 236 clusters. Each cluster contains a zwitterionic AA surrounded by seven explicit water molecules. The obtained data could evidence the effect of the side chain conformational angle (chi(1) and chi(2)) as well as the location of water molecules on the energy landscapes of both AAs. Four of the lowest energy clusters of each AA, which give rise to distinct side chain conformations, were selected in order to reproduce the FT-IR and Raman spectra recorded in aqueous solutions and to assign the vibrational modes responsible of the main observed bands. (C) 2011 American Institute of Physics. {[}doi:10.1063/1.3617415]
SP - 055101.1
EP - 055101.7
DO - 10.1063/1.3617415
UR - http://www.dx.doi.org/10.1063/1.3617415
ER -