article · 21/09/2021
Thermal modulation of Zebrafish exploratory statistics reveals constraints on individual behavioral variability
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Résumé
Variability is a hallmark of animal behavior. It endows individuals and populations with the capacity to adapt to ever-changing conditions. How variability is internally regulated and modulated by external cues remains elusive. Here we address this question by focusing on the exploratory behavior of zebrafish larvae as they freely swim at different, yet ethologically relevant, water temperatures. We show that, for this simple animal model, five short-term kinematic parameters together control the long-term exploratory dynamics. We establish that the bath temperature consistently impacts the means and variances of these parameters, but leave their pairwise covariance unchanged. These results indicate that the temperature merely controls the sampling statistics within a well-defined accessible locomotor repertoire. At a given temperature, the exploration of the behavioral space is found to take place over tens of minutes, suggestive of a slow internal state modulation that could be externally biased through the bath temperature. By combining these various observations into a minimal stochastic model of navigation, we show that this thermal modulation of locomotor kinematics results in a thermophobic behavior, complementing direct gradient-sensing mechanisms.
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Le Goc, G., Lafaye, J., Karpenko, S., Bormuth, V., Candelier, R., & Debrégeas, G. (2021). Thermal modulation of Zebrafish exploratory statistics reveals constraints on individual behavioral variability. BMC Biology, 19(1), 208. https://doi.org/https://doi.org/10.1186/s12915-021-01126-w@article{LeGoc2021_328,
author = {Le Goc, Guillaume and Lafaye, Julie and Karpenko, Sophia and Bormuth, Volker and Candelier, Raphaël and Debrégeas, Georges},
year = {2021},
month = {9},
title = {Thermal modulation of Zebrafish exploratory statistics reveals constraints on individual behavioral variability},
journal = {BMC Biology},
volume = {19},
number = {1},
pages = {208},
abstract = {Variability is a hallmark of animal behavior. It endows individuals and populations with the capacity to adapt to ever-changing conditions. How variability is internally regulated and modulated by external cues remains elusive. Here we address this question by focusing on the exploratory behavior of zebrafish larvae as they freely swim at different, yet ethologically relevant, water temperatures. We show that, for this simple animal model, five short-term kinematic parameters together control the long-term exploratory dynamics. We establish that the bath temperature consistently impacts the means and variances of these parameters, but leave their pairwise covariance unchanged. These results indicate that the temperature merely controls the sampling statistics within a well-defined accessible locomotor repertoire. At a given temperature, the exploration of the behavioral space is found to take place over tens of minutes, suggestive of a slow internal state modulation that could be externally biased through the bath temperature. By combining these various observations into a minimal stochastic model of navigation, we show that this thermal modulation of locomotor kinematics results in a thermophobic behavior, complementing direct gradient-sensing mechanisms.},
url = {https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01126-w},
doi = {https://doi.org/10.1186/s12915-021-01126-w},
issn = {1741-7007},
}TY - JOUR
AU - Le Goc, Guillaume
AU - Lafaye, Julie
AU - Karpenko, Sophia
AU - Bormuth, Volker
AU - Candelier, Raphaël
AU - Debrégeas, Georges
PY - 2021
DA - 2021/09/21
TI - Thermal modulation of Zebrafish exploratory statistics reveals constraints on individual behavioral variability
JO - BMC Biology
VL - 19
IS - 1
SN - 1741-7007
AB - Variability is a hallmark of animal behavior. It endows individuals and populations with the capacity to adapt to ever-changing conditions. How variability is internally regulated and modulated by external cues remains elusive. Here we address this question by focusing on the exploratory behavior of zebrafish larvae as they freely swim at different, yet ethologically relevant, water temperatures. We show that, for this simple animal model, five short-term kinematic parameters together control the long-term exploratory dynamics. We establish that the bath temperature consistently impacts the means and variances of these parameters, but leave their pairwise covariance unchanged. These results indicate that the temperature merely controls the sampling statistics within a well-defined accessible locomotor repertoire. At a given temperature, the exploration of the behavioral space is found to take place over tens of minutes, suggestive of a slow internal state modulation that could be externally biased through the bath temperature. By combining these various observations into a minimal stochastic model of navigation, we show that this thermal modulation of locomotor kinematics results in a thermophobic behavior, complementing direct gradient-sensing mechanisms.
SP - 208
DO - https://doi.org/10.1186/s12915-021-01126-w
UR - https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01126-w
ER -