article · 21/08/2019
Diffusion through Nanopores in Connected Lipid Bilayer Networks
Résumé
A biomimetic model of cell-cell communication was developed to probe the passive molecular transport across ion channels inserted in synthetic lipid bilayers formed between contacting droplets arranged in a linear array. Diffusion of a fluorescent probe across the array was measured for different pore concentrations. The diffusion characteristic timescale is found to vary nonlinearly with the pore concentration. Our measurements are successfully modeled by a continuous time random walk description whose waiting time is the first exit time from a droplet through a cluster of pores. The size of the cluster of pores is found to increase with their concentration. Our results provide a direct link between the mesoscopic permeation properties and the microscopic characteristics of the pores, such as their number, size, and spatial arrangement.
Citer cet article
Valet, M., Pontani, L.-L., Voituriez, R., Wandersman, E., & Prevost, A. (2019). Diffusion through Nanopores in Connected Lipid Bilayer Networks. Phys. Rev. Lett., 123(8), 088101. https://doi.org/10.1103/PhysRevLett.123.088101@article{Valet2019_319,
author = {Valet, Manon and Pontani, Léa-Laetitia and Voituriez, Raphaël and Wandersman, Elie and Prevost, Alexis},
year = {2019},
month = {8},
title = {Diffusion through Nanopores in Connected Lipid Bilayer Networks},
journal = {Phys. Rev. Lett.},
volume = {123},
number = {8},
pages = {088101},
abstract = {A biomimetic model of cell-cell communication was developed to probe the passive molecular transport across ion channels inserted in synthetic lipid bilayers formed between contacting droplets arranged in a linear array. Diffusion of a fluorescent probe across the array was measured for different pore concentrations. The diffusion characteristic timescale is found to vary nonlinearly with the pore concentration. Our measurements are successfully modeled by a continuous time random walk description whose waiting time is the first exit time from a droplet through a cluster of pores. The size of the cluster of pores is found to increase with their concentration. Our results provide a direct link between the mesoscopic permeation properties and the microscopic characteristics of the pores, such as their number, size, and spatial arrangement.},
url = {https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.123.088101},
doi = {10.1103/PhysRevLett.123.088101},
}TY - JOUR
AU - Valet, Manon
AU - Pontani, Léa-Laetitia
AU - Voituriez, Raphaël
AU - Wandersman, Elie
AU - Prevost, Alexis
PY - 2019
DA - 2019/08/21
TI - Diffusion through Nanopores in Connected Lipid Bilayer Networks
JO - Phys. Rev. Lett.
VL - 123
IS - 8
AB - A biomimetic model of cell-cell communication was developed to probe the passive molecular transport across ion channels inserted in synthetic lipid bilayers formed between contacting droplets arranged in a linear array. Diffusion of a fluorescent probe across the array was measured for different pore concentrations. The diffusion characteristic timescale is found to vary nonlinearly with the pore concentration. Our measurements are successfully modeled by a continuous time random walk description whose waiting time is the first exit time from a droplet through a cluster of pores. The size of the cluster of pores is found to increase with their concentration. Our results provide a direct link between the mesoscopic permeation properties and the microscopic characteristics of the pores, such as their number, size, and spatial arrangement.
SP - 088101
DO - 10.1103/PhysRevLett.123.088101
UR - https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.123.088101
ER -