article · 01/08/2018
Integrating Physical and Molecular Insights on Immune Cell Migration
Résumé
The function of most immune cells depends on their ability to migrate through complex microenvironments, either randomly to patrol for the presence of antigens or directionally to reach their next site of action. The actin cytoskeleton and its partners are key conductors of immune cell migration as they control the intrinsic migratory properties of leukocytes as well as their capacity to respond to cues present in their environment. In this review we focus on the latest discoveries regarding the role of the actomyosin cytoskeleton in optimizing immune cell migration in complex environments, with a special focus on recent insights provided by physical modeling.
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Moreau, H.-D., Piel, M., Voituriez, R., & Lennon-Dumenil, A.-M. (2018). Integrating Physical and Molecular Insights on Immune Cell Migration. Trends Immunol., 39(8). https://doi.org/10.1016/j.it.2018.04.007@article{Moreau2018_284,
author = {Moreau, Helene D. and Piel, Matthieu and Voituriez, Raphael and Lennon-Dumenil, Ana-Maria},
year = {2018},
month = {8},
title = {Integrating Physical and Molecular Insights on Immune Cell Migration},
journal = {Trends Immunol.},
publisher = {ELSEVIER SCI LTD},
volume = {39},
number = {8},
address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND},
abstract = {The function of most immune cells depends on their ability to migrate through complex microenvironments, either randomly to patrol for the presence of antigens or directionally to reach their next site of action. The actin cytoskeleton and its partners are key conductors of immune cell migration as they control the intrinsic migratory properties of leukocytes as well as their capacity to respond to cues present in their environment. In this review we focus on the latest discoveries regarding the role of the actomyosin cytoskeleton in optimizing immune cell migration in complex environments, with a special focus on recent insights provided by physical modeling.},
url = {http://www.dx.doi.org/10.1016/j.it.2018.04.007},
doi = {10.1016/j.it.2018.04.007},
issn = {1471-4906},
}TY - JOUR
AU - Moreau, Helene D.
AU - Piel, Matthieu
AU - Voituriez, Raphael
AU - Lennon-Dumenil, Ana-Maria
PY - 2018
DA - 2018/08/01
TI - Integrating Physical and Molecular Insights on Immune Cell Migration
JO - Trends Immunol.
VL - 39
IS - 8
PB - ELSEVIER SCI LTD
SN - 1471-4906
AB - The function of most immune cells depends on their ability to migrate through complex microenvironments, either randomly to patrol for the presence of antigens or directionally to reach their next site of action. The actin cytoskeleton and its partners are key conductors of immune cell migration as they control the intrinsic migratory properties of leukocytes as well as their capacity to respond to cues present in their environment. In this review we focus on the latest discoveries regarding the role of the actomyosin cytoskeleton in optimizing immune cell migration in complex environments, with a special focus on recent insights provided by physical modeling.
DO - 10.1016/j.it.2018.04.007
UR - http://www.dx.doi.org/10.1016/j.it.2018.04.007
ER -