article · 11/06/2018
Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Résumé
Multiciliated ependymal cells line all brain cavities. The beating of their motile cilia contributes to the flow of cerebrospinal fluid, which is required for brain homoeostasis and functions. Motile cilia, nucleated from centrioles, persist once formed and withstand the forces produced by the external fluid flow and by their own cilia beating. Here, we show that a dense actin network around the centrioles is induced by cilia beating, as shown by the disorganisation of the actin network upon impairment of cilia motility. Moreover, disruption of the actin network, or specifically of the apical actin network, causes motile cilia and their centrioles to detach from the apical surface of ependymal cell. In conclusion, cilia beating controls the apical actin network around centrioles; the mechanical resistance of this actin network contributes, in turn, to centriole stability.
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Mahuzier, A., Shihavuddin, A., Fournier, C., Lansade, P., Faucourt, M., Menezes, N., Meunier, A., Garfa-Traore, M., Carlier, M.-F., Voituriez, R., Genovesio, A., Spassky, N., & Delgehyr, N. (2018). Ependymal cilia beating induces an actin network to protect centrioles against shear stress. Nat. Commun., 9(2279). https://doi.org/10.1038/s41467-018-04676-w@article{Mahuzier2018_281,
author = {Mahuzier, Alexia and Shihavuddin, Asm and Fournier, Clemence and Lansade, Pauline and Faucourt, Marion and Menezes, Nikita and Meunier, Alice and Garfa-Traore, Meriem and Carlier, Marie-France and Voituriez, Raphael and Genovesio, Auguste and Spassky, Nathalie and Delgehyr, Nathalie},
year = {2018},
month = {6},
title = {Ependymal cilia beating induces an actin network to protect centrioles against shear stress},
journal = {Nat. Commun.},
publisher = {NATURE PUBLISHING GROUP},
volume = {9},
number = {2279},
address = {MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND},
abstract = {Multiciliated ependymal cells line all brain cavities. The beating of their motile cilia contributes to the flow of cerebrospinal fluid, which is required for brain homoeostasis and functions. Motile cilia, nucleated from centrioles, persist once formed and withstand the forces produced by the external fluid flow and by their own cilia beating. Here, we show that a dense actin network around the centrioles is induced by cilia beating, as shown by the disorganisation of the actin network upon impairment of cilia motility. Moreover, disruption of the actin network, or specifically of the apical actin network, causes motile cilia and their centrioles to detach from the apical surface of ependymal cell. In conclusion, cilia beating controls the apical actin network around centrioles; the mechanical resistance of this actin network contributes, in turn, to centriole stability.},
url = {http://www.dx.doi.org/10.1038/s41467-018-04676-w},
doi = {10.1038/s41467-018-04676-w},
issn = {2041-1723},
}TY - JOUR
AU - Mahuzier, Alexia
AU - Shihavuddin, Asm
AU - Fournier, Clemence
AU - Lansade, Pauline
AU - Faucourt, Marion
AU - Menezes, Nikita
AU - Meunier, Alice
AU - Garfa-Traore, Meriem
AU - Carlier, Marie-France
AU - Voituriez, Raphael
AU - Genovesio, Auguste
AU - Spassky, Nathalie
AU - Delgehyr, Nathalie
PY - 2018
DA - 2018/06/11
TI - Ependymal cilia beating induces an actin network to protect centrioles against shear stress
JO - Nat. Commun.
VL - 9
IS - 2279
PB - NATURE PUBLISHING GROUP
SN - 2041-1723
AB - Multiciliated ependymal cells line all brain cavities. The beating of their motile cilia contributes to the flow of cerebrospinal fluid, which is required for brain homoeostasis and functions. Motile cilia, nucleated from centrioles, persist once formed and withstand the forces produced by the external fluid flow and by their own cilia beating. Here, we show that a dense actin network around the centrioles is induced by cilia beating, as shown by the disorganisation of the actin network upon impairment of cilia motility. Moreover, disruption of the actin network, or specifically of the apical actin network, causes motile cilia and their centrioles to detach from the apical surface of ependymal cell. In conclusion, cilia beating controls the apical actin network around centrioles; the mechanical resistance of this actin network contributes, in turn, to centriole stability.
DO - 10.1038/s41467-018-04676-w
UR - http://www.dx.doi.org/10.1038/s41467-018-04676-w
ER -