article · 16/04/2018
Time rescaling reproduces EEG behavior during transition from propofol anesthesia-induced unconsciousness to consciousness
Résumé
General anesthesia (GA) is a reversible manipulation of consciousness whose mechanism is mysterious at the level of neural networks leaving space for several competing hypotheses. We recorded electrocorticography (ECoG) signals in patients who underwent intracranial monitoring during awake surgery for the treatment of cerebral tumors in functional areas of the brain. Therefore, we recorded the transition from unconsciousness to consciousness directly on the brain surface. Using frequency resolved interferometry; we studied the intermediate ECoG frequencies (4-40 Hz). In the theoretical study, we used a computational Jansen and Rit neuron model to simulate recovery of consciousness (ROC). During ROC, we found that f increased by a factor equal to 1.62 +/- 0.09, and df varied by the same factor (1.61 +/- 0.09) suggesting the existence of a scaling factor. We accelerated the time course of an unconscious EEG trace by an approximate factor 1.6 and we showed that the resulting EEG trace match the conscious state. Using the theoretical model, we successfully reproduced this behavior. We show that the recovery of consciousness corresponds to a transition in the frequency (f, df) space, which is exactly reproduced by a simple time rescaling. These findings may perhaps be applied to other altered consciousness states.
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Boussen, S., Spiegler, A., Benar, C., Carrere, M., Bartolomei, F., Metellus, P., Voituriez, R., Velly, L., Bruder, N., & Trebuchon, A. (2018). Time rescaling reproduces EEG behavior during transition from propofol anesthesia-induced unconsciousness to consciousness. Sci Rep, 8(6015). https://doi.org/10.1038/s41598-018-24405-z@article{Boussen2018_279,
author = {Boussen, S. and Spiegler, A. and Benar, C. and Carrere, M. and Bartolomei, F. and Metellus, P. and Voituriez, R. and Velly, L. and Bruder, N. and Trebuchon, A.},
year = {2018},
month = {4},
title = {Time rescaling reproduces EEG behavior during transition from propofol anesthesia-induced unconsciousness to consciousness},
journal = {Sci Rep},
publisher = {NATURE PUBLISHING GROUP},
volume = {8},
number = {6015},
address = {MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND},
abstract = {General anesthesia (GA) is a reversible manipulation of consciousness whose mechanism is mysterious at the level of neural networks leaving space for several competing hypotheses. We recorded electrocorticography (ECoG) signals in patients who underwent intracranial monitoring during awake surgery for the treatment of cerebral tumors in functional areas of the brain. Therefore, we recorded the transition from unconsciousness to consciousness directly on the brain surface. Using frequency resolved interferometry; we studied the intermediate ECoG frequencies (4-40 Hz). In the theoretical study, we used a computational Jansen and Rit neuron model to simulate recovery of consciousness (ROC). During ROC, we found that f increased by a factor equal to 1.62 +/- 0.09, and df varied by the same factor (1.61 +/- 0.09) suggesting the existence of a scaling factor. We accelerated the time course of an unconscious EEG trace by an approximate factor 1.6 and we showed that the resulting EEG trace match the conscious state. Using the theoretical model, we successfully reproduced this behavior. We show that the recovery of consciousness corresponds to a transition in the frequency (f, df) space, which is exactly reproduced by a simple time rescaling. These findings may perhaps be applied to other altered consciousness states.},
url = {http://www.dx.doi.org/10.1038/s41598-018-24405-z},
doi = {10.1038/s41598-018-24405-z},
issn = {2045-2322},
}TY - JOUR
AU - Boussen, S.
AU - Spiegler, A.
AU - Benar, C.
AU - Carrere, M.
AU - Bartolomei, F.
AU - Metellus, P.
AU - Voituriez, R.
AU - Velly, L.
AU - Bruder, N.
AU - Trebuchon, A.
PY - 2018
DA - 2018/04/16
TI - Time rescaling reproduces EEG behavior during transition from propofol anesthesia-induced unconsciousness to consciousness
JO - Sci Rep
VL - 8
IS - 6015
PB - NATURE PUBLISHING GROUP
SN - 2045-2322
AB - General anesthesia (GA) is a reversible manipulation of consciousness whose mechanism is mysterious at the level of neural networks leaving space for several competing hypotheses. We recorded electrocorticography (ECoG) signals in patients who underwent intracranial monitoring during awake surgery for the treatment of cerebral tumors in functional areas of the brain. Therefore, we recorded the transition from unconsciousness to consciousness directly on the brain surface. Using frequency resolved interferometry; we studied the intermediate ECoG frequencies (4-40 Hz). In the theoretical study, we used a computational Jansen and Rit neuron model to simulate recovery of consciousness (ROC). During ROC, we found that f increased by a factor equal to 1.62 +/- 0.09, and df varied by the same factor (1.61 +/- 0.09) suggesting the existence of a scaling factor. We accelerated the time course of an unconscious EEG trace by an approximate factor 1.6 and we showed that the resulting EEG trace match the conscious state. Using the theoretical model, we successfully reproduced this behavior. We show that the recovery of consciousness corresponds to a transition in the frequency (f, df) space, which is exactly reproduced by a simple time rescaling. These findings may perhaps be applied to other altered consciousness states.
DO - 10.1038/s41598-018-24405-z
UR - http://www.dx.doi.org/10.1038/s41598-018-24405-z
ER -