article · 24/05/2018
Phosphorescence Kinetics of Singlet Oxygen Produced by Photosensitization in Spherical Nanoparticles. Part I. Theory
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Résumé
The singlet oxygen produced by energy transfer between an excited photosensitizer (pts) and ground-state oxygen molecules plays a key role in photodynamic therapy. Different nanocarrier systems are extensively studied to promote targeted pts delivery in a host body. The phosphorescence kinetics of the singlet oxygen produced by the short laser pulse photosensitization of pts inside nanoparticles is influenced by singlet oxygen diffusion from the particles to the surrounding medium. Two theoretical models are presented in this work: a more complex numerical one and a simple analytical one. Both the models predict the time course of singlet oxygen concentration inside and outside of the spherical particles following short-pulse excitation of pts. On the basis of the comparison of the numerical and analytical results, a semiempirical analytical formula is derived to calculate the characteristic diffusion time of singlet oxygen from the nanoparticles to the surrounding solvent. The phosphorescence intensity of singlet oxygen produced in pts-loaded nanocarrier systems can be calculated as a linear combination of the two concentrations (inside and outside the particles), taking the different phosphorescence emission rate constants into account.
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Hovan, A., Datta, S., Kruglik, S.-G., Jancura, D., Miskovsky, P., & Bano, G. (2018). Phosphorescence Kinetics of Singlet Oxygen Produced by Photosensitization in Spherical Nanoparticles. Part I. Theory. J. Phys. Chem. B, 122(20), 5147-5153.. https://doi.org/10.1021/acs.jpcb.8b00658@article{Hovan2018_272,
author = {Hovan, Andrej and Datta, Shubhashis and Kruglik, Sergei G. and Jancura, Daniel and Miskovsky, Pavol and Bano, Gregor},
year = {2018},
month = {5},
title = {Phosphorescence Kinetics of Singlet Oxygen Produced by Photosensitization in Spherical Nanoparticles. Part I. Theory},
journal = {J. Phys. Chem. B},
publisher = {AMER CHEMICAL SOC},
volume = {122},
number = {20},
pages = {5147-5153.},
address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
abstract = {The singlet oxygen produced by energy transfer between an excited photosensitizer (pts) and ground-state oxygen molecules plays a key role in photodynamic therapy. Different nanocarrier systems are extensively studied to promote targeted pts delivery in a host body. The phosphorescence kinetics of the singlet oxygen produced by the short laser pulse photosensitization of pts inside nanoparticles is influenced by singlet oxygen diffusion from the particles to the surrounding medium. Two theoretical models are presented in this work: a more complex numerical one and a simple analytical one. Both the models predict the time course of singlet oxygen concentration inside and outside of the spherical particles following short-pulse excitation of pts. On the basis of the comparison of the numerical and analytical results, a semiempirical analytical formula is derived to calculate the characteristic diffusion time of singlet oxygen from the nanoparticles to the surrounding solvent. The phosphorescence intensity of singlet oxygen produced in pts-loaded nanocarrier systems can be calculated as a linear combination of the two concentrations (inside and outside the particles), taking the different phosphorescence emission rate constants into account.},
url = {http://www.dx.doi.org/10.1021/acs.jpcb.8b00658},
doi = {10.1021/acs.jpcb.8b00658},
issn = {1520-6106},
}TY - JOUR
AU - Hovan, Andrej
AU - Datta, Shubhashis
AU - Kruglik, Sergei G.
AU - Jancura, Daniel
AU - Miskovsky, Pavol
AU - Bano, Gregor
PY - 2018
DA - 2018/05/24
TI - Phosphorescence Kinetics of Singlet Oxygen Produced by Photosensitization in Spherical Nanoparticles. Part I. Theory
JO - J. Phys. Chem. B
VL - 122
IS - 20
PB - AMER CHEMICAL SOC
SN - 1520-6106
AB - The singlet oxygen produced by energy transfer between an excited photosensitizer (pts) and ground-state oxygen molecules plays a key role in photodynamic therapy. Different nanocarrier systems are extensively studied to promote targeted pts delivery in a host body. The phosphorescence kinetics of the singlet oxygen produced by the short laser pulse photosensitization of pts inside nanoparticles is influenced by singlet oxygen diffusion from the particles to the surrounding medium. Two theoretical models are presented in this work: a more complex numerical one and a simple analytical one. Both the models predict the time course of singlet oxygen concentration inside and outside of the spherical particles following short-pulse excitation of pts. On the basis of the comparison of the numerical and analytical results, a semiempirical analytical formula is derived to calculate the characteristic diffusion time of singlet oxygen from the nanoparticles to the surrounding solvent. The phosphorescence intensity of singlet oxygen produced in pts-loaded nanocarrier systems can be calculated as a linear combination of the two concentrations (inside and outside the particles), taking the different phosphorescence emission rate constants into account.
SP - 5147
EP - 5153.
DO - 10.1021/acs.jpcb.8b00658
UR - http://www.dx.doi.org/10.1021/acs.jpcb.8b00658
ER -