article · 01/11/2003
JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells
Résumé
Retinoic acid induces clinical remission in acute promyelocytic leukemia (APL) by triggering differentiation of leukemia promyelocytes. Here, we have characterized a gene encoding a member of the immunoglobulin superfamily, among novel retinoic acid-induced genes identified in APL cells. This protein, which was named JAML (junctional adhesion molecule-like), contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML mRNA is expressed in hematopoietic tissues and is prominently expressed in granulocytes. The fact that JAML protein is localized at the cell plasma membrane in the areas of cell-cell contacts, whereas it is not detected at free cell borders, suggests that JAML is engaged in homophilic interactions. Furthermore, a conserved dimerization motif among JAM members was shown to be important for JAML localization at the cell membrane. Finally, exogenous expression of JAML in myeloid leukemia cells resulted in enhanced cell adhesion to endothelial cells. Altogether, our results point to JAML as a novel member of the JAM family expressed on leukocytes with a possible role in leukocyte transmigration. (C) 2003 by The American Society of Hematology.
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Moog-Lutz, C., Cave-Riant, F., Guibal, F., Breau, M., Di Gioia, Y., Couraud, P., Cayre, Y., Bourdoulous, S., & Lutz, P. (2003). JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood, 102(9). https://doi.org/10.1182/blood-2002-11-3462@article{MoogLutz2003_256,
author = {Moog-Lutz, C and Cave-Riant, F and Guibal, FC and Breau, MA and Di Gioia, Y and Couraud, PO and Cayre, YE and Bourdoulous, S and Lutz, PG},
year = {2003},
month = {11},
title = {JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells},
journal = {Blood},
publisher = {AMER SOC HEMATOLOGY},
volume = {102},
number = {9},
address = {1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA},
abstract = {Retinoic acid induces clinical remission in acute promyelocytic leukemia (APL) by triggering differentiation of leukemia promyelocytes. Here, we have characterized a gene encoding a member of the immunoglobulin superfamily, among novel retinoic acid-induced genes identified in APL cells. This protein, which was named JAML (junctional adhesion molecule-like), contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML mRNA is expressed in hematopoietic tissues and is prominently expressed in granulocytes. The fact that JAML protein is localized at the cell plasma membrane in the areas of cell-cell contacts, whereas it is not detected at free cell borders, suggests that JAML is engaged in homophilic interactions. Furthermore, a conserved dimerization motif among JAM members was shown to be important for JAML localization at the cell membrane. Finally, exogenous expression of JAML in myeloid leukemia cells resulted in enhanced cell adhesion to endothelial cells. Altogether, our results point to JAML as a novel member of the JAM family expressed on leukocytes with a possible role in leukocyte transmigration. (C) 2003 by The American Society of Hematology.},
url = {http://www.dx.doi.org/10.1182/blood-2002-11-3462},
doi = {10.1182/blood-2002-11-3462},
issn = {0006-4971},
}TY - JOUR
AU - Moog-Lutz, C
AU - Cave-Riant, F
AU - Guibal, FC
AU - Breau, MA
AU - Di Gioia, Y
AU - Couraud, PO
AU - Cayre, YE
AU - Bourdoulous, S
AU - Lutz, PG
PY - 2003
DA - 2003/11/01
TI - JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells
JO - Blood
VL - 102
IS - 9
PB - AMER SOC HEMATOLOGY
SN - 0006-4971
AB - Retinoic acid induces clinical remission in acute promyelocytic leukemia (APL) by triggering differentiation of leukemia promyelocytes. Here, we have characterized a gene encoding a member of the immunoglobulin superfamily, among novel retinoic acid-induced genes identified in APL cells. This protein, which was named JAML (junctional adhesion molecule-like), contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML mRNA is expressed in hematopoietic tissues and is prominently expressed in granulocytes. The fact that JAML protein is localized at the cell plasma membrane in the areas of cell-cell contacts, whereas it is not detected at free cell borders, suggests that JAML is engaged in homophilic interactions. Furthermore, a conserved dimerization motif among JAM members was shown to be important for JAML localization at the cell membrane. Finally, exogenous expression of JAML in myeloid leukemia cells resulted in enhanced cell adhesion to endothelial cells. Altogether, our results point to JAML as a novel member of the JAM family expressed on leukocytes with a possible role in leukocyte transmigration. (C) 2003 by The American Society of Hematology.
DO - 10.1182/blood-2002-11-3462
UR - http://www.dx.doi.org/10.1182/blood-2002-11-3462
ER -