article · 18/02/2013
Active gel model of amoeboid cell motility
Résumé
We develop a model of amoeboid cell motility based on active gel theory. Modeling the motile apparatus of a eukaryotic cell as a confined layer of finite length of poroelastic active gel permeated by a solvent, we first show that, due to active stress and gel turnover, an initially static and homogeneous layer can undergo a contractile-type instability to a polarized moving state in which the rear is enriched in gel polymer. This agrees qualitatively with motile cells containing an actomyosin-rich uropod at their rear. We find that the gel layer settles into a steadily moving, inhomogeneous state at long times, sustained by a balance between contractility and filament turnover. In addition, our model predicts an optimal value of the gel-substrate adhesion leading to maximum layer speed, in agreement with cell motility assays. The model may be relevant to motility of cells translocating in complex, confining environments that can be mimicked experimentally by cell migration through microchannels.
Citer cet article
Callan-Jones, A.-C., & Voituriez, R. (2013). Active gel model of amoeboid cell motility. NEW JOURNAL OF PHYSICS, 15(025022). https://doi.org/10.1088/1367-2630/15/2/025022@article{CallanJones2013_238,
author = {Callan-Jones, A. C. and Voituriez, R.},
year = {2013},
month = {2},
title = {Active gel model of amoeboid cell motility},
journal = {NEW JOURNAL OF PHYSICS},
volume = {15},
number = {025022},
abstract = {We develop a model of amoeboid cell motility based on active gel theory. Modeling the motile apparatus of a eukaryotic cell as a confined layer of finite length of poroelastic active gel permeated by a solvent, we first show that, due to active stress and gel turnover, an initially static and homogeneous layer can undergo a contractile-type instability to a polarized moving state in which the rear is enriched in gel polymer. This agrees qualitatively with motile cells containing an actomyosin-rich uropod at their rear. We find that the gel layer settles into a steadily moving, inhomogeneous state at long times, sustained by a balance between contractility and filament turnover. In addition, our model predicts an optimal value of the gel-substrate adhesion leading to maximum layer speed, in agreement with cell motility assays. The model may be relevant to motility of cells translocating in complex, confining environments that can be mimicked experimentally by cell migration through microchannels.},
url = {http://www.dx.doi.org/10.1088/1367-2630/15/2/025022},
doi = {10.1088/1367-2630/15/2/025022},
issn = {1367-2630},
}TY - JOUR
AU - Callan-Jones, A. C.
AU - Voituriez, R.
PY - 2013
DA - 2013/02/18
TI - Active gel model of amoeboid cell motility
JO - NEW JOURNAL OF PHYSICS
VL - 15
IS - 025022
SN - 1367-2630
AB - We develop a model of amoeboid cell motility based on active gel theory. Modeling the motile apparatus of a eukaryotic cell as a confined layer of finite length of poroelastic active gel permeated by a solvent, we first show that, due to active stress and gel turnover, an initially static and homogeneous layer can undergo a contractile-type instability to a polarized moving state in which the rear is enriched in gel polymer. This agrees qualitatively with motile cells containing an actomyosin-rich uropod at their rear. We find that the gel layer settles into a steadily moving, inhomogeneous state at long times, sustained by a balance between contractility and filament turnover. In addition, our model predicts an optimal value of the gel-substrate adhesion leading to maximum layer speed, in agreement with cell motility assays. The model may be relevant to motility of cells translocating in complex, confining environments that can be mimicked experimentally by cell migration through microchannels.
DO - 10.1088/1367-2630/15/2/025022
UR - http://www.dx.doi.org/10.1088/1367-2630/15/2/025022
ER -