article · 01/11/2013
Migration of dendritic cells: physical principles, molecular mechanisms, and functional implications
Résumé
Dendritic cells (DCs) constitute a complex cell population that resides in both peripheral tissues and lymphoid organs. Their major function in tissues is to patrol their environment in search of danger-associated antigens to transport to lymph nodes and present to T lymphocytes. This process constitutes the first step of the adaptive immune response and relies on specific DC properties, including a high endocytic capacity as well as efficient motility in confined three-dimensional environments. Although cell motility has been widely studied, little is known on how the geometric characteristics of the environment influence DC migration and function. In this review, we give an overview of the basic physical principles and molecular mechanisms that control DC migration under confinement and discuss how such mechanisms impact the environment-patrolling capacity of DCs.
Citer cet article
Heuze, M.-L., Vargas, P., Chabaud, M., Le Berre, M., Liu, Y.-J., Collin, O., Solanes, P., Voituriez, R., Piel, M., & Lennon-Dumenil, A.-M. (2013). Migration of dendritic cells: physical principles, molecular mechanisms, and functional implications. IMMUNOLOGICAL REVIEWS, 256(1, SI). https://doi.org/10.1111/imr.12108@article{Heuze2013_230,
author = {Heuze, Melina L. and Vargas, Pablo and Chabaud, Melanie and Le Berre, Mael and Liu, Yan-Jun and Collin, Olivier and Solanes, Paola and Voituriez, Raphael and Piel, Matthieu and Lennon-Dumenil, Ana-Maria},
year = {2013},
month = {11},
title = {Migration of dendritic cells: physical principles, molecular mechanisms, and functional implications},
journal = {IMMUNOLOGICAL REVIEWS},
volume = {256},
number = {1, SI},
abstract = {Dendritic cells (DCs) constitute a complex cell population that resides in both peripheral tissues and lymphoid organs. Their major function in tissues is to patrol their environment in search of danger-associated antigens to transport to lymph nodes and present to T lymphocytes. This process constitutes the first step of the adaptive immune response and relies on specific DC properties, including a high endocytic capacity as well as efficient motility in confined three-dimensional environments. Although cell motility has been widely studied, little is known on how the geometric characteristics of the environment influence DC migration and function. In this review, we give an overview of the basic physical principles and molecular mechanisms that control DC migration under confinement and discuss how such mechanisms impact the environment-patrolling capacity of DCs.},
url = {http://www.dx.doi.org/10.1111/imr.12108},
doi = {10.1111/imr.12108},
issn = {0105-2896},
}TY - JOUR
AU - Heuze, Melina L.
AU - Vargas, Pablo
AU - Chabaud, Melanie
AU - Le Berre, Mael
AU - Liu, Yan-Jun
AU - Collin, Olivier
AU - Solanes, Paola
AU - Voituriez, Raphael
AU - Piel, Matthieu
AU - Lennon-Dumenil, Ana-Maria
PY - 2013
DA - 2013/11/01
TI - Migration of dendritic cells: physical principles, molecular mechanisms, and functional implications
JO - IMMUNOLOGICAL REVIEWS
VL - 256
IS - 1, SI
SN - 0105-2896
AB - Dendritic cells (DCs) constitute a complex cell population that resides in both peripheral tissues and lymphoid organs. Their major function in tissues is to patrol their environment in search of danger-associated antigens to transport to lymph nodes and present to T lymphocytes. This process constitutes the first step of the adaptive immune response and relies on specific DC properties, including a high endocytic capacity as well as efficient motility in confined three-dimensional environments. Although cell motility has been widely studied, little is known on how the geometric characteristics of the environment influence DC migration and function. In this review, we give an overview of the basic physical principles and molecular mechanisms that control DC migration under confinement and discuss how such mechanisms impact the environment-patrolling capacity of DCs.
DO - 10.1111/imr.12108
UR - http://www.dx.doi.org/10.1111/imr.12108
ER -