article · 07/11/2013
Geometric Friction Directs Cell Migration
Résumé
In the absence of environmental cues, a migrating cell performs an isotropic random motion. Recently, the breaking of this isotropy has been observed when cells move in the presence of asymmetric adhesive patterns. However, up to now the mechanisms at work to direct cell migration in such environments remain unknown. Here, we show that a nonadhesive surface with asymmetric microgeometry consisting of dense arrays of tilted micropillars can direct cell motion. Our analysis reveals that most features of cell trajectories, including the bias, can be reproduced by a simple model of active Brownian particle in a ratchet potential, which we suggest originates from a generic elastic interaction of the cell body with the environment. The observed guiding effect, independent of adhesion, is therefore robust and could be used to direct cell migration both in vitro and in vivo.
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Le Berre, M., Liu, Y.-J., Hu, J., Maiuri, P., Benichou, O., Voituriez, R., Chen, Y., & Piel, M. (2013). Geometric Friction Directs Cell Migration. PHYSICAL REVIEW LETTERS, 111(19). https://doi.org/10.1103/PhysRevLett.111.198101@article{LeBerre2013_229,
author = {Le Berre, M. and Liu, Yan-Jun and Hu, J. and Maiuri, Paolo and Benichou, O. and Voituriez, R. and Chen, Y. and Piel, M.},
year = {2013},
month = {11},
title = {Geometric Friction Directs Cell Migration},
journal = {PHYSICAL REVIEW LETTERS},
volume = {111},
number = {19},
abstract = {In the absence of environmental cues, a migrating cell performs an isotropic random motion. Recently, the breaking of this isotropy has been observed when cells move in the presence of asymmetric adhesive patterns. However, up to now the mechanisms at work to direct cell migration in such environments remain unknown. Here, we show that a nonadhesive surface with asymmetric microgeometry consisting of dense arrays of tilted micropillars can direct cell motion. Our analysis reveals that most features of cell trajectories, including the bias, can be reproduced by a simple model of active Brownian particle in a ratchet potential, which we suggest originates from a generic elastic interaction of the cell body with the environment. The observed guiding effect, independent of adhesion, is therefore robust and could be used to direct cell migration both in vitro and in vivo.},
url = {http://www.dx.doi.org/10.1103/PhysRevLett.111.198101},
doi = {10.1103/PhysRevLett.111.198101},
issn = {0031-9007},
}TY - JOUR
AU - Le Berre, M.
AU - Liu, Yan-Jun
AU - Hu, J.
AU - Maiuri, Paolo
AU - Benichou, O.
AU - Voituriez, R.
AU - Chen, Y.
AU - Piel, M.
PY - 2013
DA - 2013/11/07
TI - Geometric Friction Directs Cell Migration
JO - PHYSICAL REVIEW LETTERS
VL - 111
IS - 19
SN - 0031-9007
AB - In the absence of environmental cues, a migrating cell performs an isotropic random motion. Recently, the breaking of this isotropy has been observed when cells move in the presence of asymmetric adhesive patterns. However, up to now the mechanisms at work to direct cell migration in such environments remain unknown. Here, we show that a nonadhesive surface with asymmetric microgeometry consisting of dense arrays of tilted micropillars can direct cell motion. Our analysis reveals that most features of cell trajectories, including the bias, can be reproduced by a simple model of active Brownian particle in a ratchet potential, which we suggest originates from a generic elastic interaction of the cell body with the environment. The observed guiding effect, independent of adhesion, is therefore robust and could be used to direct cell migration both in vitro and in vivo.
DO - 10.1103/PhysRevLett.111.198101
UR - http://www.dx.doi.org/10.1103/PhysRevLett.111.198101
ER -