article · 12/02/2015
Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells
Résumé
The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how confinement and adhesion affect this transition. We report that, in the absence of focal adhesions and under conditions of confinement, mesenchymal cells can spontaneously switch to a fast amoeboid migration phenotype. We identified two main types of fast migration-one involving a local protrusion and a second involving a myosin-II-dependent mechanical instability of the cell cortex that leads to a global cortical flow. Interestingly, transformed cells are more prone to adopt this fast migration mode. Finally, we propose a generic model that explains migration transitions and predicts a phase diagram of migration phenotypes based on three main control parameters: confinement, adhesion, and contractility.
Citer cet article
Liu, Y.-J., Le Berre, M., Lautenschlaeger, F., Maiuri, P., Callan-Jones, A., Heuze, M., Takaki, T., Voituriez, R., & Piel, M. (2015). Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells. CELL, 160(4). https://doi.org/10.1016/j.cell.2015.01.007@article{Liu2015_206,
author = {Liu, Yan-Jun and Le Berre, Mael and Lautenschlaeger, Franziska and Maiuri, Paolo and Callan-Jones, Andrew and Heuze, Melina and Takaki, Tohru and Voituriez, Raphael and Piel, Matthieu},
year = {2015},
month = {2},
title = {Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells},
journal = {CELL},
volume = {160},
number = {4},
abstract = {The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how confinement and adhesion affect this transition. We report that, in the absence of focal adhesions and under conditions of confinement, mesenchymal cells can spontaneously switch to a fast amoeboid migration phenotype. We identified two main types of fast migration-one involving a local protrusion and a second involving a myosin-II-dependent mechanical instability of the cell cortex that leads to a global cortical flow. Interestingly, transformed cells are more prone to adopt this fast migration mode. Finally, we propose a generic model that explains migration transitions and predicts a phase diagram of migration phenotypes based on three main control parameters: confinement, adhesion, and contractility.},
url = {http://www.dx.doi.org/10.1016/j.cell.2015.01.007},
doi = {10.1016/j.cell.2015.01.007},
issn = {0092-8674},
}TY - JOUR
AU - Liu, Yan-Jun
AU - Le Berre, Mael
AU - Lautenschlaeger, Franziska
AU - Maiuri, Paolo
AU - Callan-Jones, Andrew
AU - Heuze, Melina
AU - Takaki, Tohru
AU - Voituriez, Raphael
AU - Piel, Matthieu
PY - 2015
DA - 2015/02/12
TI - Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells
JO - CELL
VL - 160
IS - 4
SN - 0092-8674
AB - The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how confinement and adhesion affect this transition. We report that, in the absence of focal adhesions and under conditions of confinement, mesenchymal cells can spontaneously switch to a fast amoeboid migration phenotype. We identified two main types of fast migration-one involving a local protrusion and a second involving a myosin-II-dependent mechanical instability of the cell cortex that leads to a global cortical flow. Interestingly, transformed cells are more prone to adopt this fast migration mode. Finally, we propose a generic model that explains migration transitions and predicts a phase diagram of migration phenotypes based on three main control parameters: confinement, adhesion, and contractility.
DO - 10.1016/j.cell.2015.01.007
UR - http://www.dx.doi.org/10.1016/j.cell.2015.01.007
ER -