article · 01/06/2015
Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells
Résumé
The immune response relies on the migration of leukocytes and on their ability to stop in precise anatomical locations to fulfil their task. How leukocyte migration and function are coordinated is unknown. Here we show that in immature dendritic cells, which patrol their environment by engulfing extracellular material, cell migration and antigen capture are antagonistic. This antagonism results from transient enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting antigen capture. We further highlight that myosin IIA enrichment at the cell front requires the MHC class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization, Ii imposes on dendritic cells an intermittent antigen capture behaviour that might facilitate environment patrolling. We propose that the requirement for myosin II in both cell migration and specific cell functions may provide a general mechanism for their coordination in time and space.
Citer cet article
Chabaud, M., Heuze, M.-L., Bretou, M., Vargas, P., Maiuri, P., Solanes, P., Maurin, M., Terriac, E., Le Berre, M., Lankar, D., Piolot, T., Adelstein, R.-S., Zhang, Y., Sixt, M., Jacobelli, J., Benichou, O., Voituriez, R., Piel, M., & Lennon-Dumenil, A.-M. (2015). Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. NATURE COMMUNICATIONS, 6(7526). https://doi.org/10.1038/ncomms8526@article{Chabaud2015_197,
author = {Chabaud, Melanie and Heuze, Melina L. and Bretou, Marine and Vargas, Pablo and Maiuri, Paolo and Solanes, Paola and Maurin, Mathieu and Terriac, Emmanuel and Le Berre, Mael and Lankar, Danielle and Piolot, Tristan and Adelstein, Robert S. and Zhang, Yingfan and Sixt, Michael and Jacobelli, Jordan and Benichou, Olivier and Voituriez, Raphael and Piel, Matthieu and Lennon-Dumenil, Ana-Maria},
year = {2015},
month = {6},
title = {Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells},
journal = {NATURE COMMUNICATIONS},
volume = {6},
number = {7526},
abstract = {The immune response relies on the migration of leukocytes and on their ability to stop in precise anatomical locations to fulfil their task. How leukocyte migration and function are coordinated is unknown. Here we show that in immature dendritic cells, which patrol their environment by engulfing extracellular material, cell migration and antigen capture are antagonistic. This antagonism results from transient enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting antigen capture. We further highlight that myosin IIA enrichment at the cell front requires the MHC class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization, Ii imposes on dendritic cells an intermittent antigen capture behaviour that might facilitate environment patrolling. We propose that the requirement for myosin II in both cell migration and specific cell functions may provide a general mechanism for their coordination in time and space.},
url = {http://www.dx.doi.org/10.1038/ncomms8526},
doi = {10.1038/ncomms8526},
issn = {2041-1723},
}TY - JOUR
AU - Chabaud, Melanie
AU - Heuze, Melina L.
AU - Bretou, Marine
AU - Vargas, Pablo
AU - Maiuri, Paolo
AU - Solanes, Paola
AU - Maurin, Mathieu
AU - Terriac, Emmanuel
AU - Le Berre, Mael
AU - Lankar, Danielle
AU - Piolot, Tristan
AU - Adelstein, Robert S.
AU - Zhang, Yingfan
AU - Sixt, Michael
AU - Jacobelli, Jordan
AU - Benichou, Olivier
AU - Voituriez, Raphael
AU - Piel, Matthieu
AU - Lennon-Dumenil, Ana-Maria
PY - 2015
DA - 2015/06/01
TI - Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells
JO - NATURE COMMUNICATIONS
VL - 6
IS - 7526
SN - 2041-1723
AB - The immune response relies on the migration of leukocytes and on their ability to stop in precise anatomical locations to fulfil their task. How leukocyte migration and function are coordinated is unknown. Here we show that in immature dendritic cells, which patrol their environment by engulfing extracellular material, cell migration and antigen capture are antagonistic. This antagonism results from transient enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting antigen capture. We further highlight that myosin IIA enrichment at the cell front requires the MHC class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization, Ii imposes on dendritic cells an intermittent antigen capture behaviour that might facilitate environment patrolling. We propose that the requirement for myosin II in both cell migration and specific cell functions may provide a general mechanism for their coordination in time and space.
DO - 10.1038/ncomms8526
UR - http://www.dx.doi.org/10.1038/ncomms8526
ER -