article · 01/12/2015
Ratchetaxis: Long-Range Directed Cell Migration by Local Cues
Résumé
Directed cell migration is usually thought to depend on the presence of long-range gradients of either chemoattractants or physical properties such as stiffness or adhesion. However, in vivo, chemical or mechanical gradients have not systematically been observed. Here we review recent in vitro experiments, which show that other types of spatial guidance cues can bias cell motility. Introducing local geometrical or mechanical anisotropy in the cell environment, such as adhesive/topographical microratchets or tilted micropillars, show that local and periodic external cues can direct cell motion. Together with modeling, these experiments suggest that cell motility can be viewed as a stochastic phenomenon, which can be biased by various types of local cues, leading to directional migration.
Citer cet article
Caballero, D., Comelles, J., Piel, M., Voituriez, R., & Riveline, D. (2015). Ratchetaxis: Long-Range Directed Cell Migration by Local Cues. TRENDS IN CELL BIOLOGY, 25(12, SI). https://doi.org/10.1016/j.tcb.2015.10.009@article{Caballero2015_185,
author = {Caballero, David and Comelles, Jordi and Piel, Matthieu and Voituriez, Raphael and Riveline, Daniel},
year = {2015},
month = {12},
title = {Ratchetaxis: Long-Range Directed Cell Migration by Local Cues},
journal = {TRENDS IN CELL BIOLOGY},
volume = {25},
number = {12, SI},
abstract = {Directed cell migration is usually thought to depend on the presence of long-range gradients of either chemoattractants or physical properties such as stiffness or adhesion. However, in vivo, chemical or mechanical gradients have not systematically been observed. Here we review recent in vitro experiments, which show that other types of spatial guidance cues can bias cell motility. Introducing local geometrical or mechanical anisotropy in the cell environment, such as adhesive/topographical microratchets or tilted micropillars, show that local and periodic external cues can direct cell motion. Together with modeling, these experiments suggest that cell motility can be viewed as a stochastic phenomenon, which can be biased by various types of local cues, leading to directional migration.},
url = {http://www.dx.doi.org/10.1016/j.tcb.2015.10.009},
doi = {10.1016/j.tcb.2015.10.009},
issn = {0962-8924},
}TY - JOUR
AU - Caballero, David
AU - Comelles, Jordi
AU - Piel, Matthieu
AU - Voituriez, Raphael
AU - Riveline, Daniel
PY - 2015
DA - 2015/12/01
TI - Ratchetaxis: Long-Range Directed Cell Migration by Local Cues
JO - TRENDS IN CELL BIOLOGY
VL - 25
IS - 12, SI
SN - 0962-8924
AB - Directed cell migration is usually thought to depend on the presence of long-range gradients of either chemoattractants or physical properties such as stiffness or adhesion. However, in vivo, chemical or mechanical gradients have not systematically been observed. Here we review recent in vitro experiments, which show that other types of spatial guidance cues can bias cell motility. Introducing local geometrical or mechanical anisotropy in the cell environment, such as adhesive/topographical microratchets or tilted micropillars, show that local and periodic external cues can direct cell motion. Together with modeling, these experiments suggest that cell motility can be viewed as a stochastic phenomenon, which can be biased by various types of local cues, leading to directional migration.
DO - 10.1016/j.tcb.2015.10.009
UR - http://www.dx.doi.org/10.1016/j.tcb.2015.10.009
ER -