article · 02/09/2016
Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling
Résumé
Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This mechanosensitive process can direct early cell adhesion, cell migration and even cell differentiation. These processes require the integration of signals over time and multiple length scales. Multiple strategies have been developed to understand force- and rigidity-sensing mechanisms and much effort has been concentrated on the study of cell adhesion complexes, such as focal adhesions, and cell cytoskeletons. Here, we review the major biophysical methods used for measuring cell-traction forces as well as the mechanosensitive processes that drive cellular responses to matrix rigidity on 2-dimensional substrates.
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Gupta, M., Doss, B., Lim, C.-T., Voituriez, R., & Ladoux, B. (2016). Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling. CELL ADHESION \& MIGRATION, 10(5). https://doi.org/10.1080/19336918.2016.1173800@article{Gupta2016_183,
author = {Gupta, Mukund and Doss, Bryant and Lim, Chwee Teck and Voituriez, Raphael and Ladoux, Benoit},
year = {2016},
month = {9},
title = {Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling},
journal = {CELL ADHESION \textbackslash{}\& MIGRATION},
volume = {10},
number = {5},
abstract = {Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This mechanosensitive process can direct early cell adhesion, cell migration and even cell differentiation. These processes require the integration of signals over time and multiple length scales. Multiple strategies have been developed to understand force- and rigidity-sensing mechanisms and much effort has been concentrated on the study of cell adhesion complexes, such as focal adhesions, and cell cytoskeletons. Here, we review the major biophysical methods used for measuring cell-traction forces as well as the mechanosensitive processes that drive cellular responses to matrix rigidity on 2-dimensional substrates.},
url = {http://www.dx.doi.org/10.1080/19336918.2016.1173800},
doi = {10.1080/19336918.2016.1173800},
issn = {1933-6918},
}TY - JOUR
AU - Gupta, Mukund
AU - Doss, Bryant
AU - Lim, Chwee Teck
AU - Voituriez, Raphael
AU - Ladoux, Benoit
PY - 2016
DA - 2016/09/02
TI - Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling
JO - CELL ADHESION \& MIGRATION
VL - 10
IS - 5
SN - 1933-6918
AB - Many physiological and pathological processes involve tissue cells sensing the rigidity of their environment. In general, tissue cells have been shown to react to the stiffness of their environment by regulating their level of contractility, and in turn applying traction forces on their environment to probe it. This mechanosensitive process can direct early cell adhesion, cell migration and even cell differentiation. These processes require the integration of signals over time and multiple length scales. Multiple strategies have been developed to understand force- and rigidity-sensing mechanisms and much effort has been concentrated on the study of cell adhesion complexes, such as focal adhesions, and cell cytoskeletons. Here, we review the major biophysical methods used for measuring cell-traction forces as well as the mechanosensitive processes that drive cellular responses to matrix rigidity on 2-dimensional substrates.
DO - 10.1080/19336918.2016.1173800
UR - http://www.dx.doi.org/10.1080/19336918.2016.1173800
ER -