article · 15/01/2016
Cortical Flow-Driven Shapes of Nonadherent Cells
Résumé
Nonadherent polarized cells have been observed to have a pearlike, elongated shape. Using a minimal model that describes the cell cortex as a thin layer of contractile active gel, we show that the anisotropy of active stresses, controlled by cortical viscosity and filament ordering, can account for this morphology. The predicted shapes can be determined from the flow pattern only; they prove to be independent of the mechanism at the origin of the cortical flow, and are only weakly sensitive to the cytoplasmic rheology. In the case of actin flows resulting from a contractile instability, we propose a phase diagram of three-dimensional cell shapes that encompasses nonpolarized spherical, elongated, as well as oblate shapes, all of which have been observed in experiment.
Citer cet article
Callan-Jones, A., Ruprecht, V., Wieser, S., Heisenberg, C.-P., & Voituriez, R. (2016). Cortical Flow-Driven Shapes of Nonadherent Cells. PHYSICAL REVIEW LETTERS, 116(2). https://doi.org/10.1103/PhysRevLett.116.028102@article{CallanJones2016_180,
author = {Callan-Jones, A.C. and Ruprecht, V. and Wieser, S. and Heisenberg, C. P. and Voituriez, R.},
year = {2016},
month = {1},
title = {Cortical Flow-Driven Shapes of Nonadherent Cells},
journal = {PHYSICAL REVIEW LETTERS},
volume = {116},
number = {2},
abstract = {Nonadherent polarized cells have been observed to have a pearlike, elongated shape. Using a minimal model that describes the cell cortex as a thin layer of contractile active gel, we show that the anisotropy of active stresses, controlled by cortical viscosity and filament ordering, can account for this morphology. The predicted shapes can be determined from the flow pattern only; they prove to be independent of the mechanism at the origin of the cortical flow, and are only weakly sensitive to the cytoplasmic rheology. In the case of actin flows resulting from a contractile instability, we propose a phase diagram of three-dimensional cell shapes that encompasses nonpolarized spherical, elongated, as well as oblate shapes, all of which have been observed in experiment.},
url = {http://www.dx.doi.org/10.1103/PhysRevLett.116.028102},
doi = {10.1103/PhysRevLett.116.028102},
issn = {0031-9007},
}TY - JOUR
AU - Callan-Jones, A.C.
AU - Ruprecht, V.
AU - Wieser, S.
AU - Heisenberg, C. P.
AU - Voituriez, R.
PY - 2016
DA - 2016/01/15
TI - Cortical Flow-Driven Shapes of Nonadherent Cells
JO - PHYSICAL REVIEW LETTERS
VL - 116
IS - 2
SN - 0031-9007
AB - Nonadherent polarized cells have been observed to have a pearlike, elongated shape. Using a minimal model that describes the cell cortex as a thin layer of contractile active gel, we show that the anisotropy of active stresses, controlled by cortical viscosity and filament ordering, can account for this morphology. The predicted shapes can be determined from the flow pattern only; they prove to be independent of the mechanism at the origin of the cortical flow, and are only weakly sensitive to the cytoplasmic rheology. In the case of actin flows resulting from a contractile instability, we propose a phase diagram of three-dimensional cell shapes that encompasses nonpolarized spherical, elongated, as well as oblate shapes, all of which have been observed in experiment.
DO - 10.1103/PhysRevLett.116.028102
UR - http://www.dx.doi.org/10.1103/PhysRevLett.116.028102
ER -