article · 01/02/2016
Actin flows in cell migration: from locomotion and polarity to trajectories
Résumé
Eukaryotic cell movement is characterized by very diverse migration modes. Recent studies show that cells can adapt to environmental cues, such as adhesion and geometric confinement, thereby readily switching their mode of migration. Among this diversity of motile behavior, actin flows have emerged as a highly conserved feature of both mesenchymal and amoeboid migration, and have also been identified as key regulators of cell polarity. This suggests that the various observed migration modes are continuous variations of elementary locomotion mechanisms, based on a very robust physical property of the actin/myosin system - its ability to sustain flows at the cell scale. This central role of actin/myosin flows is shown to affect the large scale properties of cell trajectories.
Citer cet article
Callan-Jones, A.-C., & Voituriez, R. (2016). Actin flows in cell migration: from locomotion and polarity to trajectories. CURRENT OPINION IN CELL BIOLOGY, 38. https://doi.org/10.1016/j.ceb.2016.01.003@article{CallanJones2016_179,
author = {Callan-Jones, Andrew C. and Voituriez, Raphael},
year = {2016},
month = {2},
title = {Actin flows in cell migration: from locomotion and polarity to trajectories},
journal = {CURRENT OPINION IN CELL BIOLOGY},
volume = {38},
abstract = {Eukaryotic cell movement is characterized by very diverse migration modes. Recent studies show that cells can adapt to environmental cues, such as adhesion and geometric confinement, thereby readily switching their mode of migration. Among this diversity of motile behavior, actin flows have emerged as a highly conserved feature of both mesenchymal and amoeboid migration, and have also been identified as key regulators of cell polarity. This suggests that the various observed migration modes are continuous variations of elementary locomotion mechanisms, based on a very robust physical property of the actin/myosin system - its ability to sustain flows at the cell scale. This central role of actin/myosin flows is shown to affect the large scale properties of cell trajectories.},
url = {http://www.dx.doi.org/10.1016/j.ceb.2016.01.003},
doi = {10.1016/j.ceb.2016.01.003},
issn = {0955-0674},
}TY - JOUR
AU - Callan-Jones, Andrew C.
AU - Voituriez, Raphael
PY - 2016
DA - 2016/02/01
TI - Actin flows in cell migration: from locomotion and polarity to trajectories
JO - CURRENT OPINION IN CELL BIOLOGY
VL - 38
SN - 0955-0674
AB - Eukaryotic cell movement is characterized by very diverse migration modes. Recent studies show that cells can adapt to environmental cues, such as adhesion and geometric confinement, thereby readily switching their mode of migration. Among this diversity of motile behavior, actin flows have emerged as a highly conserved feature of both mesenchymal and amoeboid migration, and have also been identified as key regulators of cell polarity. This suggests that the various observed migration modes are continuous variations of elementary locomotion mechanisms, based on a very robust physical property of the actin/myosin system - its ability to sustain flows at the cell scale. This central role of actin/myosin flows is shown to affect the large scale properties of cell trajectories.
DO - 10.1016/j.ceb.2016.01.003
UR - http://www.dx.doi.org/10.1016/j.ceb.2016.01.003
ER -