article · 01/12/2016
Deterministic patterns in cell motility
Résumé
Cell migration paths are generally described as random walks, associated with both intrinsic and extrinsic noise. However, complex cell locomotion is not merely related to such fluctuations, but is often determined by the underlying machinery. Cell motility is driven mechanically by actin and myosin, two molecular components that generate contractile forces. Other cell functions make use of the same components and, therefore, will compete with the migratory apparatus. Here, we propose a physical model of such a competitive system, namely dendritic cells whose antigen capture function and migratory ability are coupled by myosin II. The model predicts that this coupling gives rise to a dynamic instability, whereby cells switch from persistent migration to unidirectional self-oscillation, through a Hopf bifurcation. Cells can then switch to periodic polarity reversals through a homoclinic bifurcation. These predicted dynamic regimes are characterized by robust features that we identify through in vitro trajectories of dendritic cells over long timescales and distances. We expect that competition for limited resources in other migrating cell types can lead to similar deterministic migration modes.
Citer cet article
Lavi, I., Piel, M., Lennon-Dumenil, A.-M., Voituriez, R., & Gov, N.-S. (2016). Deterministic patterns in cell motility. Nature Physics, 12(12). https://doi.org/10.1038/NPHYS3836@article{Lavi2016_170,
author = {Lavi, Ido and Piel, Matthieu and Lennon-Dumenil, Ana-Maria and Voituriez, Raphael and Gov, Nir S.},
year = {2016},
month = {12},
title = {Deterministic patterns in cell motility},
journal = {Nature Physics},
volume = {12},
number = {12},
abstract = {Cell migration paths are generally described as random walks, associated with both intrinsic and extrinsic noise. However, complex cell locomotion is not merely related to such fluctuations, but is often determined by the underlying machinery. Cell motility is driven mechanically by actin and myosin, two molecular components that generate contractile forces. Other cell functions make use of the same components and, therefore, will compete with the migratory apparatus. Here, we propose a physical model of such a competitive system, namely dendritic cells whose antigen capture function and migratory ability are coupled by myosin II. The model predicts that this coupling gives rise to a dynamic instability, whereby cells switch from persistent migration to unidirectional self-oscillation, through a Hopf bifurcation. Cells can then switch to periodic polarity reversals through a homoclinic bifurcation. These predicted dynamic regimes are characterized by robust features that we identify through in vitro trajectories of dendritic cells over long timescales and distances. We expect that competition for limited resources in other migrating cell types can lead to similar deterministic migration modes.},
url = {http://www.dx.doi.org/10.1038/NPHYS3836},
doi = {10.1038/NPHYS3836},
issn = {1745-2473},
}TY - JOUR
AU - Lavi, Ido
AU - Piel, Matthieu
AU - Lennon-Dumenil, Ana-Maria
AU - Voituriez, Raphael
AU - Gov, Nir S.
PY - 2016
DA - 2016/12/01
TI - Deterministic patterns in cell motility
JO - Nature Physics
VL - 12
IS - 12
SN - 1745-2473
AB - Cell migration paths are generally described as random walks, associated with both intrinsic and extrinsic noise. However, complex cell locomotion is not merely related to such fluctuations, but is often determined by the underlying machinery. Cell motility is driven mechanically by actin and myosin, two molecular components that generate contractile forces. Other cell functions make use of the same components and, therefore, will compete with the migratory apparatus. Here, we propose a physical model of such a competitive system, namely dendritic cells whose antigen capture function and migratory ability are coupled by myosin II. The model predicts that this coupling gives rise to a dynamic instability, whereby cells switch from persistent migration to unidirectional self-oscillation, through a Hopf bifurcation. Cells can then switch to periodic polarity reversals through a homoclinic bifurcation. These predicted dynamic regimes are characterized by robust features that we identify through in vitro trajectories of dendritic cells over long timescales and distances. We expect that competition for limited resources in other migrating cell types can lead to similar deterministic migration modes.
DO - 10.1038/NPHYS3836
UR - http://www.dx.doi.org/10.1038/NPHYS3836
ER -