article · 09/04/2015
Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence
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Résumé
Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.
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Maiuri, P., Rupprecht, J.-F., Wieser, S., Ruprecht, V., Benichou, O., Carpi, N., Coppey, M., De Beco, S., Gov, N., Heisenberg, C.-P., Crespo, C.-L., Lautenschlaeger, F., Le Berre, M., Lennon-Dumenil, A.-M., Raab, M., Thiam, H.-R., Piel, M., Sixt, M., & Voituriez, R. (2015). Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence. Cell, 161(2). https://doi.org/10.1016/j.cell.2015.01.056@article{Maiuri2015_17,
author = {Maiuri, Paolo and Rupprecht, Jean-Francois and Wieser, Stefan and Ruprecht, Verena and Benichou, Olivier and Carpi, Nicolas and Coppey, Mathieu and De Beco, Simon and Gov, Nir and Heisenberg, Carl-Philipp and Crespo, Carolina Lage and Lautenschlaeger, Franziska and Le Berre, Maeil and Lennon-Dumenil, Ana-Maria and Raab, Matthew and Thiam, Hawa-Racine and Piel, Matthieu and Sixt, Michael and Voituriez, Raphael},
year = {2015},
month = {4},
title = {Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence},
journal = {Cell},
publisher = {CELL PRESS},
volume = {161},
number = {2},
address = {600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA},
abstract = {Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.},
url = {http://www.dx.doi.org/10.1016/j.cell.2015.01.056},
doi = {10.1016/j.cell.2015.01.056},
issn = {0092-8674},
}TY - JOUR
AU - Maiuri, Paolo
AU - Rupprecht, Jean-Francois
AU - Wieser, Stefan
AU - Ruprecht, Verena
AU - Benichou, Olivier
AU - Carpi, Nicolas
AU - Coppey, Mathieu
AU - De Beco, Simon
AU - Gov, Nir
AU - Heisenberg, Carl-Philipp
AU - Crespo, Carolina Lage
AU - Lautenschlaeger, Franziska
AU - Le Berre, Maeil
AU - Lennon-Dumenil, Ana-Maria
AU - Raab, Matthew
AU - Thiam, Hawa-Racine
AU - Piel, Matthieu
AU - Sixt, Michael
AU - Voituriez, Raphael
PY - 2015
DA - 2015/04/09
TI - Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence
JO - Cell
VL - 161
IS - 2
PB - CELL PRESS
SN - 0092-8674
AB - Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.
DO - 10.1016/j.cell.2015.01.056
UR - http://www.dx.doi.org/10.1016/j.cell.2015.01.056
ER -