article · 01/09/2008
Tetrapyrrole photosensitisers, determinants of subcellular localisation and mechanisms of photodynamic processes in therapeutic approaches
Résumé
Background: Tetrapyrrole photosensitisers are the main drugs used in the various photodynamic therapies. They are based on light-induced reactive oxygen species whose lifetimes are very short, limiting their diffusion in space. The photoinduced alterations primarily affect the labelled structures, at the systemic and subcellular levels. Thus, in parallel to the improvement of the photophysical and photochemical properties of photosensitisers, focus has been given to the parameters governing their localisation. Objectives and Methods: We analyse the parameters that support the efficiency of photosensitisers, paying particular attention to their structural and physicochemical characteristics, especially the dynamics of photosenitisers towards membranes. Conclusion: The determinants of systemic and subcellular targeting are discussed with regard to the induced response.
Citer cet article
Bonneau, S., & Vever-Bizet, C. (2008). Tetrapyrrole photosensitisers, determinants of subcellular localisation and mechanisms of photodynamic processes in therapeutic approaches. Expert Opinion on Therapeutic Patents, 18(9), 1011-1025. https://doi.org/10.1517/13543770802303368@article{Bonneau2008_156,
author = {Bonneau, Stephanie and Vever-Bizet, Christine},
year = {2008},
month = {9},
title = {Tetrapyrrole photosensitisers, determinants of subcellular localisation and mechanisms of photodynamic processes in therapeutic approaches},
journal = {Expert Opinion on Therapeutic Patents},
volume = {18},
number = {9},
pages = {1011-1025},
abstract = {Background: Tetrapyrrole photosensitisers are the main drugs used in the various photodynamic therapies. They are based on light-induced reactive oxygen species whose lifetimes are very short, limiting their diffusion in space. The photoinduced alterations primarily affect the labelled structures, at the systemic and subcellular levels. Thus, in parallel to the improvement of the photophysical and photochemical properties of photosensitisers, focus has been given to the parameters governing their localisation. Objectives and Methods: We analyse the parameters that support the efficiency of photosensitisers, paying particular attention to their structural and physicochemical characteristics, especially the dynamics of photosenitisers towards membranes. Conclusion: The determinants of systemic and subcellular targeting are discussed with regard to the induced response.},
url = {http://www.dx.doi.org/10.1517/13543770802303368},
doi = {10.1517/13543770802303368},
issn = {1354-3776},
}TY - JOUR
AU - Bonneau, Stephanie
AU - Vever-Bizet, Christine
PY - 2008
DA - 2008/09/01
TI - Tetrapyrrole photosensitisers, determinants of subcellular localisation and mechanisms of photodynamic processes in therapeutic approaches
JO - Expert Opinion on Therapeutic Patents
VL - 18
IS - 9
SN - 1354-3776
AB - Background: Tetrapyrrole photosensitisers are the main drugs used in the various photodynamic therapies. They are based on light-induced reactive oxygen species whose lifetimes are very short, limiting their diffusion in space. The photoinduced alterations primarily affect the labelled structures, at the systemic and subcellular levels. Thus, in parallel to the improvement of the photophysical and photochemical properties of photosensitisers, focus has been given to the parameters governing their localisation. Objectives and Methods: We analyse the parameters that support the efficiency of photosensitisers, paying particular attention to their structural and physicochemical characteristics, especially the dynamics of photosenitisers towards membranes. Conclusion: The determinants of systemic and subcellular targeting are discussed with regard to the induced response.
SP - 1011
EP - 1025
DO - 10.1517/13543770802303368
UR - http://www.dx.doi.org/10.1517/13543770802303368
ER -