article · 14/09/2017
Sensorimotor computation underlying phototaxis in zebrafish
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Résumé
Animals continuously gather sensory cues in order to move towards favourable environments. Efficient goal-directed navigation requires sensory perception and motor commands to be intertwined in a feedback loop, yet the neural substrate underlying this sensorimotor task in the vertebrate brain remains elusive. Here, we combine virtual-reality behavioural assays, volumetric calcium imaging, optogenetic stimulation, and circuit modelling to reveal the neural mechanisms through which a zebrafish performs phototaxis, i.e. actively orients towards a light source. Key to this process is a self-oscillating hindbrain population (HBO) that acts as a pacemaker for ocular saccades and controls the orientation of successive swim-bouts. It further integrates visual stimuli in a state-dependent manner, i.e. its response to visual inputs varies with the motor context, a mechanism that manifests itself in the phase-locked entrainment of the HBO by periodic stimuli. A rate model is developed that reproduces our observations and demonstrates how this sensorimotor processing eventually biases the animal trajectory towards bright regions.
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Wolf, S., Dubreuil, A., Bertoni, T., Böhm, U.-L., Bormuth, V., Candelier, R., Karpenko, S., Hildebrand, D.-G.-C., H. Bianco, I., Monasson, R., & Debrégeas, G. (2017). Sensorimotor computation underlying phototaxis in zebrafish. Nature Communication, 8(651). https://doi.org/10.1038/s41467-017-00310-3@article{Wolf2017_148,
author = {Wolf, Sébastien and Dubreuil, Alexis and Bertoni, Tommaso and Böhm, Urs Lucas and Bormuth, Volker and Candelier, Raphaël and Karpenko, Sophia and Hildebrand, David G. C. and H. Bianco, Isaac and Monasson, Rémi and Debrégeas, Georges},
year = {2017},
month = {9},
title = {Sensorimotor computation underlying phototaxis in zebrafish},
journal = {Nature Communication},
volume = {8},
number = {651},
abstract = {Animals continuously gather sensory cues in order to move towards favourable environments. Efficient goal-directed navigation requires sensory perception and motor commands to be intertwined in a feedback loop, yet the neural substrate underlying this sensorimotor task in the vertebrate brain remains elusive. Here, we combine virtual-reality behavioural assays, volumetric calcium imaging, optogenetic stimulation, and circuit modelling to reveal the neural mechanisms through which a zebrafish performs phototaxis, i.e. actively orients towards a light source. Key to this process is a self-oscillating hindbrain population (HBO) that acts as a pacemaker for ocular saccades and controls the orientation of successive swim-bouts. It further integrates visual stimuli in a state-dependent manner, i.e. its response to visual inputs varies with the motor context, a mechanism that manifests itself in the phase-locked entrainment of the HBO by periodic stimuli. A rate model is developed that reproduces our observations and demonstrates how this sensorimotor processing eventually biases the animal trajectory towards bright regions.},
doi = {10.1038/s41467-017-00310-3},
}TY - JOUR
AU - Wolf, Sébastien
AU - Dubreuil, Alexis
AU - Bertoni, Tommaso
AU - Böhm, Urs Lucas
AU - Bormuth, Volker
AU - Candelier, Raphaël
AU - Karpenko, Sophia
AU - Hildebrand, David G. C.
AU - H. Bianco, Isaac
AU - Monasson, Rémi
AU - Debrégeas, Georges
PY - 2017
DA - 2017/09/14
TI - Sensorimotor computation underlying phototaxis in zebrafish
JO - Nature Communication
VL - 8
IS - 651
AB - Animals continuously gather sensory cues in order to move towards favourable environments. Efficient goal-directed navigation requires sensory perception and motor commands to be intertwined in a feedback loop, yet the neural substrate underlying this sensorimotor task in the vertebrate brain remains elusive. Here, we combine virtual-reality behavioural assays, volumetric calcium imaging, optogenetic stimulation, and circuit modelling to reveal the neural mechanisms through which a zebrafish performs phototaxis, i.e. actively orients towards a light source. Key to this process is a self-oscillating hindbrain population (HBO) that acts as a pacemaker for ocular saccades and controls the orientation of successive swim-bouts. It further integrates visual stimuli in a state-dependent manner, i.e. its response to visual inputs varies with the motor context, a mechanism that manifests itself in the phase-locked entrainment of the HBO by periodic stimuli. A rate model is developed that reproduces our observations and demonstrates how this sensorimotor processing eventually biases the animal trajectory towards bright regions.
DO - 10.1038/s41467-017-00310-3
ER -