article · 01/08/2004
Injection and flow control system for microchannels
Résumé
In spite of considerable efforts, flow control in micro-channels remains a challenge owing to the very small ratio of channel/supply-system volumes, as well as the induction of spurious flows by extremely small pressure or geometry changes. We present here an inexpensive and robust system for flow control in a microchannel system, based on a dynamic control of reservoir pressures at the end of each channel. This system allows flow equilibration with a time constant smaller than one second, and is also able to maintain stable flux from stopped flow to many mul min(-1) range over several hours. It is robust to changes in ambient pressure and temperature. This system further includes a feature for sub-microliter sample injection during the experiment. We quantify flow control in elastomer and thermoplastic channels, and demonstrate the impact on one application of the system, namely the reproducible, automated separation of large DNA by electrophoresis in a selforganized magnetic bead matrix in a microchannel.
Citer cet article
Futterer, C., Minc, N., Bormuth, V., Codarbox, J., Laval, P., Rossier, J., & Viovy, J. (2004). Injection and flow control system for microchannels. Lab Chip, 4(4). https://doi.org/10.1039/B316729A@article{Futterer2004_141,
author = {Futterer, C and Minc, N and Bormuth, V and Codarbox, JH and Laval, P and Rossier, J and Viovy, JL},
year = {2004},
month = {8},
title = {Injection and flow control system for microchannels},
journal = {Lab Chip},
publisher = {ROYAL SOC CHEMISTRY},
volume = {4},
number = {4},
address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
abstract = {In spite of considerable efforts, flow control in micro-channels remains a challenge owing to the very small ratio of channel/supply-system volumes, as well as the induction of spurious flows by extremely small pressure or geometry changes. We present here an inexpensive and robust system for flow control in a microchannel system, based on a dynamic control of reservoir pressures at the end of each channel. This system allows flow equilibration with a time constant smaller than one second, and is also able to maintain stable flux from stopped flow to many mul min(-1) range over several hours. It is robust to changes in ambient pressure and temperature. This system further includes a feature for sub-microliter sample injection during the experiment. We quantify flow control in elastomer and thermoplastic channels, and demonstrate the impact on one application of the system, namely the reproducible, automated separation of large DNA by electrophoresis in a selforganized magnetic bead matrix in a microchannel.},
url = {http://www.dx.doi.org/10.1039/B316729A},
doi = {10.1039/B316729A},
issn = {1473-0189},
}TY - JOUR
AU - Futterer, C
AU - Minc, N
AU - Bormuth, V
AU - Codarbox, JH
AU - Laval, P
AU - Rossier, J
AU - Viovy, JL
PY - 2004
DA - 2004/08/01
TI - Injection and flow control system for microchannels
JO - Lab Chip
VL - 4
IS - 4
PB - ROYAL SOC CHEMISTRY
SN - 1473-0189
AB - In spite of considerable efforts, flow control in micro-channels remains a challenge owing to the very small ratio of channel/supply-system volumes, as well as the induction of spurious flows by extremely small pressure or geometry changes. We present here an inexpensive and robust system for flow control in a microchannel system, based on a dynamic control of reservoir pressures at the end of each channel. This system allows flow equilibration with a time constant smaller than one second, and is also able to maintain stable flux from stopped flow to many mul min(-1) range over several hours. It is robust to changes in ambient pressure and temperature. This system further includes a feature for sub-microliter sample injection during the experiment. We quantify flow control in elastomer and thermoplastic channels, and demonstrate the impact on one application of the system, namely the reproducible, automated separation of large DNA by electrophoresis in a selforganized magnetic bead matrix in a microchannel.
DO - 10.1039/B316729A
UR - http://www.dx.doi.org/10.1039/B316729A
ER -