proceeding · 01/01/2015
Hair-Bundle Friction from Transduction Channels' Gating Forces
Résumé
Hearing starts when sound-evoked mechanical vibrations of the hair-cell bundle activate mechanosensitive ion channels, giving birth to an electrical signal. As for any mechanical system, friction impedes movements of the hair bundle and thus constrains the sensitivity and frequency selectivity of auditory transduction. We have shown recently that the opening and closing of the transduction channels produce internal frictional forces that can dominate viscous drag on the micrometer-sized hair bundle and thus provide a major source of damping {[}2]. We develop here a physical theory of passive hair-bundle mechanics that explains the origin of channel friction. We show that channel friction can be understood quantitatively by coupling the dynamics of the conformational change associated with channel gating to tip-link tension. As a result, varying channel properties affects friction, with faster channels producing smaller friction. The analysis emphasizes the dual role of transduction channels' gating forces, which affect both hair-bundle stiffness and drag. Friction originating from gating of ion channels is a general concept that is relevant to all mechanosensitive channels.
Citer cet article
Bormuth, V., Barral, J., Joanny, J.-F., Juelicher, F., & Martin, P. (2015). Hair-Bundle Friction from Transduction Channels' Gating Forces. MECHANICS OF HEARING: PROTEIN TO PERCEPTION, 1703(030003). https://doi.org/10.1063/1.4939318@inproceedings{Bormuth2015_126,
author = {Bormuth, Volker and Barral, Jeremie and Joanny, Jean-Francois and Juelicher, Frank and Martin, Pascal},
year = {2015},
month = {1},
title = {Hair-Bundle Friction from Transduction Channels' Gating Forces},
booktitle = {MECHANICS OF HEARING: PROTEIN TO PERCEPTION},
publisher = {AMER INST PHYSICS},
volume = {1703},
number = {030003},
series = {AIP Conference Proceedings},
address = {2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA},
abstract = {Hearing starts when sound-evoked mechanical vibrations of the hair-cell bundle activate mechanosensitive ion channels, giving birth to an electrical signal. As for any mechanical system, friction impedes movements of the hair bundle and thus constrains the sensitivity and frequency selectivity of auditory transduction. We have shown recently that the opening and closing of the transduction channels produce internal frictional forces that can dominate viscous drag on the micrometer-sized hair bundle and thus provide a major source of damping \{[\}2]. We develop here a physical theory of passive hair-bundle mechanics that explains the origin of channel friction. We show that channel friction can be understood quantitatively by coupling the dynamics of the conformational change associated with channel gating to tip-link tension. As a result, varying channel properties affects friction, with faster channels producing smaller friction. The analysis emphasizes the dual role of transduction channels' gating forces, which affect both hair-bundle stiffness and drag. Friction originating from gating of ion channels is a general concept that is relevant to all mechanosensitive channels.},
note = {12th International Workshop on the Mechanics of Hearing, Cape Sounio, GREECE, JUN 23-29, 2014},
url = {http://www.dx.doi.org/10.1063/1.4939318},
doi = {10.1063/1.4939318},
issn = {0094-243X},
}TY - CONF
AU - Bormuth, Volker
AU - Barral, Jeremie
AU - Joanny, Jean-Francois
AU - Juelicher, Frank
AU - Martin, Pascal
PY - 2015
DA - 2015/01/01
TI - Hair-Bundle Friction from Transduction Channels' Gating Forces
BT - MECHANICS OF HEARING: PROTEIN TO PERCEPTION
VL - 1703
IS - 030003
PB - AMER INST PHYSICS
SN - 0094-243X
AB - Hearing starts when sound-evoked mechanical vibrations of the hair-cell bundle activate mechanosensitive ion channels, giving birth to an electrical signal. As for any mechanical system, friction impedes movements of the hair bundle and thus constrains the sensitivity and frequency selectivity of auditory transduction. We have shown recently that the opening and closing of the transduction channels produce internal frictional forces that can dominate viscous drag on the micrometer-sized hair bundle and thus provide a major source of damping {[}2]. We develop here a physical theory of passive hair-bundle mechanics that explains the origin of channel friction. We show that channel friction can be understood quantitatively by coupling the dynamics of the conformational change associated with channel gating to tip-link tension. As a result, varying channel properties affects friction, with faster channels producing smaller friction. The analysis emphasizes the dual role of transduction channels' gating forces, which affect both hair-bundle stiffness and drag. Friction originating from gating of ion channels is a general concept that is relevant to all mechanosensitive channels.
DO - 10.1063/1.4939318
UR - http://www.dx.doi.org/10.1063/1.4939318
ER -